Fmoc-Asp(OtBu)-OSu
Fmoc-Asp(OtBu)-OSu (CAS: 78553-23-8), with the molecular formula C27H28N2O8 and a molecular weight of 508.52 g/mol, is a crucial building block in peptide synthesis. It is an N-protected derivative of aspartic acid, featuring a tert-butyl ester and an N-hydroxysuccinimide active ester. This compound is primarily utilised in solid-phase peptide synthesis (SPPS) and solution-phase synthesis for the controlled introduction of aspartic acid residues into peptide chains.
- IUPAC
- Fmoc-L-aspartic acid 4-tert-butyl 1-(hydroxysuccinimide) ester
- Synonyms
- Fmoc-L-Aspartic acid 4-tert-butyl 1-(N-hydroxysuccinimide) esterFmoc-Asp(OtBu)-ONSu
Solid-Phase Peptide Synthesis (SPPS)
Fmoc-Asp(OtBu)-OSu is widely employed in SPPS, a common method for constructing peptides. The Fmoc protecting group allows for base-labile deprotection, while the tert-butyl ester protects the side-chain carboxylic acid during coupling steps.
Solution-Phase Peptide Synthesis
In solution-phase synthesis, this derivative facilitates the controlled assembly of peptide fragments. Its activated ester form allows for efficient coupling with amine-terminated peptide chains or amino acids.
Biochemical Research
This compound serves as a valuable reagent in research laboratories for synthesising peptides with specific sequences and functionalities, aiding in the study of protein structure and function.
Development of Peptide Therapeutics
It is instrumental in the synthesis of complex peptides and peptidomimetics investigated for therapeutic applications, allowing for precise structural modifications.
| Molecular weight | 508.52 |
|---|---|
| Empirical formula | C27H28N2O8 |
| Assay | ≥98.0% (calc. based on dry substance, CN) |
| Optical activity | [α]20/D −31±1°, c = 1% in DMF |
| Storage temperature | −20°C |
| Melting point | 128-132 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Asp(OtBu)-OSu used for?
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Fmoc-Asp(OtBu)-OSu is used as a building block in solid-phase and solution-phase peptide synthesis for the introduction of N-terminally protected L-aspartic acid residues with a tert-butyl ester-protected side chain.
What is the CAS number and formula for Fmoc-Asp(OtBu)-OSu?
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The CAS number is 78553-23-8 and the empirical formula is C27H28N2O8.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Asp(OtBu)-OSu with a purity of ≥98.0% (calculated based on dry substance). TSS does not represent this product as USP, BP, or EP grade.
How should Fmoc-Asp(OtBu)-OSu be handled safely?
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When handling Fmoc-Asp(OtBu)-OSu, it is essential to wear eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used if airborne exposure is possible. This compound has a WGK Germany rating of 3.
How is Fmoc-Asp(OtBu)-OSu stored and shipped?
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Fmoc-Asp(OtBu)-OSu should be stored at −20°C. TSS offers global export services for this product.
How can I request a sample or quote for Fmoc-Asp(OtBu)-OSu?
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To request a sample or a quote for Fmoc-Asp(OtBu)-OSu, please contact our sales team through the website or by phone.
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