Fmoc-Asp-NH2
Fmoc-Asp-NH2 (CAS: 200335-40-6) is an N-terminal protected aspartic acid derivative with the molecular formula C19H18N2O5 and a molecular weight of 354.36 g/mol. It serves as a key building block in solid-phase peptide synthesis (SPPS). This compound is essential for introducing aspartic acid residues with an amide C-terminus into peptide chains, facilitating the creation of complex peptides and peptidomimetics for research and development.
- IUPAC
- Fmoc-L-isoasparagine
- Synonyms
- Fmoc-L-isoasparagine
Peptide Synthesis
Fmoc-Asp-NH2 is a crucial reagent in the Fmoc/tBu strategy for solid-phase peptide synthesis. It allows for the controlled incorporation of aspartic acid with a protected side chain and an amide terminus into growing peptide chains.
Chemical Biology Research
This derivative is utilised in chemical biology to synthesise peptides with specific structural features, aiding in the study of protein function, enzyme activity, and molecular interactions.
Pharmaceutical Intermediate Synthesis
Its role extends to the synthesis of more complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs) that require aspartic acid moieties within their structure.
Organic Synthesis
As a versatile amino acid derivative, Fmoc-Asp-NH2 can be employed in various organic synthesis routes for the construction of novel molecules and materials.
| Molecular weight | 354.36 |
|---|---|
| Empirical formula | C19H18N2O5 |
| Assay | ≥98.0% |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Asp-NH2 used for?
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Fmoc-Asp-NH2 is primarily used as a building block in solid-phase peptide synthesis (SPPS), particularly within the Fmoc/tBu strategy, to incorporate aspartic acid residues with an amide C-terminus into peptides for research in chemical biology and pharmaceutical intermediate synthesis.
What is the CAS number and molecular formula for Fmoc-Asp-NH2?
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The CAS number for Fmoc-Asp-NH2 is 200335-40-6, and its molecular formula is C19H18N2O5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Asp-NH2 with an assay of ≥98.0%. This product is intended for research and laboratory use. Tech Serve Solutions does not represent this product as USP, EP, BP, or pharmacopoeia grade.
How should Fmoc-Asp-NH2 be handled and stored?
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Fmoc-Asp-NH2 should be stored at 2-8°C. When handling, it is essential to use appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or P1 (EN143) respirator filter, due to its potential hazards (WGK Germany: 3).
How is Fmoc-Asp-NH2 packed and shipped?
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Fmoc-Asp-NH2 is carefully packed to maintain its integrity during transport and is exported globally by Tech Serve Solutions. Specific packaging details can be provided upon request.
How can I request a quote or sample for Fmoc-Asp-NH2?
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To request a quote or sample of Fmoc-Asp-NH2, please contact the Tech Serve Solutions sales team through our website or by phone, providing your specific requirements.
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