Fmoc-Asp(OtBu)-OPfp

CAS 86061-01-0C29H24F5NO6Chemical Synthesis

Fmoc-Asp(OtBu)-OPfp (CAS 86061-01-0) is a derivative of L-aspartic acid with a tert-butyl ester protecting group and a pentafluorophenyl ester activating group. Its empirical formula is C29H24F5NO6, and it has a molecular weight of 577.50 g/mol. This compound is primarily utilised in peptide synthesis and chemical biology due to its role in forming specific peptide bonds and facilitating controlled amino acid coupling.

IUPAC: N-α-Fmoc-L-aspartic acid β-tert-butyl ester pentafluorophenyl ester

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Fmoc-Asp(OtBu)-OPfp (C29H24F5NO6) — chemical structure, CAS 86061-01-0; Chemistry, fine chemical supplied by Tech Serve Solutions

Amino Acid DerivativesAsparagineChemical BiologyChemical SynthesisPeptide Chemistry

01 /Applications

Peptide Synthesis

Fmoc-Asp(OtBu)-OPfp serves as a crucial building block in solid-phase peptide synthesis (SPPS) and solution-phase methods. The Fmoc group enables base-labile deprotection, while the tert-butyl ester protects the side-chain carboxyl group. The pentafluorophenyl ester facilitates efficient coupling to the growing peptide chain.

Chemical Synthesis

This compound is employed in various chemical synthesis strategies where controlled introduction of aspartic acid with orthogonal protection is required. Its activated ester form allows for targeted amide bond formation in complex organic synthesis pathways.

Chemical Biology Research

In chemical biology, Fmoc-Asp(OtBu)-OPfp aids in the synthesis of modified peptides and peptidomimetics for studying biological processes or developing novel therapeutic agents. It enables the incorporation of aspartic acid residues into peptides with specific side-chain modifications.

02 /Properties

Molecular weight	577.50
Empirical formula	C29H24F5NO6
Assay	≥97.0%
Storage temperature	2-8°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

86061-01-0

MDL number

MFCD00037633

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Fmoc-Asp(OtBu)-OPfp used for?

Fmoc-Asp(OtBu)-OPfp is primarily used in peptide synthesis and general chemical synthesis, particularly in research and development settings within chemical biology and organic chemistry.

What is the CAS number and formula for Fmoc-Asp(OtBu)-OPfp?

The CAS number for Fmoc-Asp(OtBu)-OPfp is 86061-01-0, and its empirical formula is C29H24F5NO6.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Fmoc-Asp(OtBu)-OPfp with an assay of ≥97.0%. This product is intended for research and technical use and is not represented as USP, BP, EP, or pharmacopoeia grade.

How should Fmoc-Asp(OtBu)-OPfp be handled and stored?

Handle Fmoc-Asp(OtBu)-OPfp with appropriate personal protective equipment, including eyeshields and gloves. A respirator filter such as type N95 (US) or P1 (EN143) is recommended. Store the compound at 2-8°C to maintain its stability.

Is Fmoc-Asp(OtBu)-OPfp a controlled substance?

The provided data does not indicate that Fmoc-Asp(OtBu)-OPfp is a controlled substance.

How are your chemicals packed, shipped, and exported?

Tech Serve Solutions ensures chemicals are securely packed for safe transit and are expertly handled for global export, adhering to all relevant shipping regulations.