3,5-Difluorobenzoyl chloride
3,5-Difluorobenzoyl chloride (CAS: 129714-97-2), with the molecular formula F2C6H3COCl and a molecular weight of 176.55 g/mol, is a key organic fluorinated building block. It functions as a reactive acid halide, crucial in organic synthesis. This compound has found application in the preparation of complex pharmaceutical intermediates, particularly in the development of novel therapeutic agents.
- Synonyms
- F2C6H3COCl
Pharmaceutical Intermediate Synthesis
3,5-Difluorobenzoyl chloride serves as a valuable reagent in the synthesis of active pharmaceutical ingredients (APIs). Its specific structure facilitates the introduction of the 3,5-difluorobenzoyl moiety into target molecules, contributing to the development of new drug candidates.
Research and Development
As a fluorinated building block, it is employed in academic and industrial research settings. Researchers utilise it for creating novel organic compounds with tailored properties, exploring new chemical transformations and expanding the scope of synthetic chemistry.
Synthesis of LY450108-[14C]
This compound was specifically utilised in the synthesis of AMPA potentiator LY450108-[<sup>14</sup>C], which contained a <sup>14</sup>C-label. This highlights its role in the preparation of radiolabelled compounds for biochemical and pharmacological studies.
| Molecular weight | 176.55 |
|---|---|
| Linear formula | F2C6H3COCl |
| Assay | 98% |
| Refractive index | n20/D 1.5031(lit.) |
| Application | 3,5-Difluorobenzoyl chloride was used in the synthesis of AMPA (α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) potentiator LY450108-[14C] containing 14C-label attached to the chiral center of the molecule1. |
Hazard statements
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 69 °C / 156.2 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-36/37 |
| Safety statements (S) | 23-26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,5-Difluorobenzoyl chloride used for?
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3,5-Difluorobenzoyl chloride is primarily used as a building block in organic synthesis, particularly in the pharmaceutical industry for the preparation of active pharmaceutical ingredients and in research and development for creating novel fluorinated organic compounds.
What is the CAS number and molecular formula for 3,5-Difluorobenzoyl chloride?
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The CAS number for 3,5-Difluorobenzoyl chloride is 129714-97-2, and its linear molecular formula is F2C6H3COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3,5-Difluorobenzoyl chloride with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
How should 3,5-Difluorobenzoyl chloride be handled?
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3,5-Difluorobenzoyl chloride is a corrosive substance (Danger, H314-H335) that can cause severe skin burns and eye damage, and may irritate the respiratory tract. Appropriate personal protective equipment, including gloves, goggles, a face shield, and respiratory protection, is essential. Handle in a well-ventilated area.
Is 3,5-Difluorobenzoyl chloride available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 3,5-Difluorobenzoyl chloride.
How can I request a quote or sample for 3,5-Difluorobenzoyl chloride?
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To request a quote or sample for 3,5-Difluorobenzoyl chloride, please contact our sales team through our website or by phone.
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