3,5-Difluorobenzylsulfonyl chloride
3,5-Difluorobenzylsulfonyl chloride (CAS 163295-74-7) is a fluorinated organic building block with the molecular formula C7H5ClF2O2S and a molecular weight of 226.63 g/mol. This compound serves as a valuable intermediate in organic synthesis, particularly for introducing the 3,5-difluorobenzylsulfonyl moiety into target molecules. Its reactivity makes it suitable for various chemical transformations in the development of pharmaceuticals and agrochemicals.
- IUPAC
- (3,5-Difluorophenyl)methanesulfonyl chloride
- Synonyms
- C7H5ClF2O2S(3,5-Difluorophenyl)methanesulfonyl chloride

Organic Synthesis Intermediate
Utilised in the synthesis of complex organic molecules, this compound acts as a key building block. It is particularly useful for the introduction of fluorinated aromatic groups and sulfonyl functionalities.
Pharmaceutical Research
Serves as a precursor in the development of novel pharmaceutical agents. The incorporation of fluorine atoms can modulate a drug candidate's pharmacokinetic and pharmacodynamic properties.
Agrochemical Development
Employed in the design and synthesis of new agrochemical compounds, such as pesticides and herbicides. Fluorinated moieties can enhance efficacy and stability in agricultural applications.
Material Science
May find application in the synthesis of specialty materials where its specific structural features are beneficial for modifying material properties.
| Molecular weight | 226.63 |
|---|---|
| Empirical formula | C7H5ClF2O2S |
| Assay | 97% |
| Storage temperature | −20°C |
| Melting point | 61-65 °C |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Transport (UN / ADR) | UN 3261 8 / PGII |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,5-Difluorobenzylsulfonyl chloride used for?
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3,5-Difluorobenzylsulfonyl chloride (CAS 163295-74-7) is primarily used as an intermediate in organic synthesis, particularly for the preparation of fluorinated compounds in pharmaceutical and agrochemical research.
What is the CAS number and molecular formula for 3,5-Difluorobenzylsulfonyl chloride?
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The CAS number is 163295-74-7 and the molecular formula is C7H5ClF2O2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3,5-Difluorobenzylsulfonyl chloride with a minimum assay of 97%. This product is intended for research and chemical synthesis purposes and is not supplied as USP, BP, EP, or pharmaceutical grade.
How should 3,5-Difluorobenzylsulfonyl chloride be handled safely?
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This compound is classified as Danger, with hazard statement H314 indicating it causes severe skin burns and eye damage. Handle with appropriate personal protective equipment, including gloves, eye protection, and protective clothing, in a well-ventilated area. Refer to the Safety Data Sheet (SDS) for detailed handling instructions.
Is this chemical packed, shipped, or exported by TSS?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 3,5-Difluorobenzylsulfonyl chloride, which is shipped according to international regulations (UN 3261, Class 8, PG II).
How can I request a quote or sample for 3,5-Difluorobenzylsulfonyl chloride?
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To request a quote or sample, please contact our sales department via the website or provide your details through the product inquiry form.
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