2-(Trifluoromethyl)-1,4-phenylenediamine
2-(Trifluoromethyl)-1,4-phenylenediamine (CAS 364-13-6) is an organic compound with the linear formula CF₃C₆H₃(NH₂)₂ and a molecular weight of 176.14 g/mol. This aromatic diamine is a valuable building block in organic synthesis. It is primarily utilised in chemical research and development for the creation of more complex molecules, particularly within the pharmaceutical and materials science sectors.
- IUPAC
- 2,5-Diaminobenzotrifluoride
- Synonyms
- 2,5-Diaminobenzotrifluoride1,4-Benzenediamine, 2-(trifluoromethyl)-

Organic Synthesis Intermediate
Serves as a key intermediate in the synthesis of various organic compounds, including heterocyclic systems and complex amines. Its difunctional nature allows for diverse chemical transformations.
Pharmaceutical Research
Utilised as a building block in the discovery and development of new pharmaceutical agents. The trifluoromethyl group can impart unique electronic and lipophilic properties to drug candidates.
Materials Science
Can be employed in the synthesis of novel polymers and advanced materials. The diamine structure is suitable for polycondensation reactions.
| Molecular weight | 176.14 |
|---|---|
| Linear formula | CF3C6H3(NH2)2 |
| Assay | 97% |
| Melting point | 54-58 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 110 °C / 230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-(Trifluoromethyl)-1,4-phenylenediamine used for?
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It is primarily used as a building block in organic synthesis, particularly in pharmaceutical research and materials science for the creation of novel compounds and polymers.
What is the CAS number and formula for 2-(Trifluoromethyl)-1,4-phenylenediamine?
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The CAS number is 364-13-6 and the linear formula is CF₃C₆H₃(NH₂)₂.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound at a minimum purity of 97%. We do not represent this product as USP, BP, EP, or pharmaceutical grade.
How should 2-(Trifluoromethyl)-1,4-phenylenediamine be handled safely?
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Handle with appropriate personal protective equipment, including a dust mask (N95 recommended), eyeshields, and gloves. Avoid breathing dust and ensure adequate ventilation. It is classified as a Warning substance, causing skin irritation, serious eye irritation, and respiratory irritation (H315-H319-H335).
Is 2-(Trifluoromethyl)-1,4-phenylenediamine exported internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals.
How can I request a sample or quote for 2-(Trifluoromethyl)-1,4-phenylenediamine?
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Please contact our sales team or use the online enquiry form on our website to request a sample or a quotation.
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