2,4-Difluorophenylacetic acid
2,4-Difluorophenylacetic acid (CAS 81228-09-3) is a fluorinated organic building block with the molecular formula F₂C₆H₃CH₂CO₂H and a molar mass of 172.13 g/mol. This aryl compound functions as a carboxylic acid and is utilised in chemical synthesis, particularly as a precursor for specialised molecules. Its structure makes it valuable in the development of novel materials and intermediates within the pharmaceutical and chemical industries.
- Synonyms
- 2,4-Difluorophenylacetic acidF2C6H3CH2CO2H
Synthesis of Fluoro-Aromatic Compounds
2,4-Difluorophenylacetic acid serves as a key intermediate in the synthesis of molecules incorporating fluoroaromatic moieties. These are often pursued for their unique electronic and lipophilic properties in drug discovery and materials science.
Building Block for Peptide Nucleic Acid Monomers
This compound has been employed in the synthesis of nonpolar peptide nucleic acid (PNA) monomers that feature fluoroaromatic components. Such modifications can alter the biophysical properties of nucleic acid analogues.
Organic Synthesis Intermediate
As a versatile carboxylic acid derivative, it is utilised in various organic transformations. Its difluorinated phenyl ring provides specific reactivity and structural characteristics for constructing more complex organic molecules.
| Molecular weight | 172.13 |
|---|---|
| Linear formula | F2C6H3CH2CO2H |
| Assay | 97% |
| Application | 2,4-Difluorophenylacetic acid has been used in the synthesis of nonpolar peptide nucleic acid monomers containing fluoroaromatics (F-PNA)1. |
| Melting point | 115-118 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,4-Difluorophenylacetic acid used for?
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2,4-Difluorophenylacetic acid is primarily used as an intermediate in organic synthesis and as a building block for creating specialised molecules, including fluoroaromatic compounds and modified peptide nucleic acid monomers.
What is the CAS number and formula for 2,4-Difluorophenylacetic acid?
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The CAS number for 2,4-Difluorophenylacetic acid is 81228-09-3, and its linear formula is F₂C₆H₃CH₂CO₂H.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,4-Difluorophenylacetic acid with an assay of 97%. We do not represent this product as USP, BP, EP or other pharmacopoeial grades.
How should 2,4-Difluorophenylacetic acid be handled safely?
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Handle 2,4-Difluorophenylacetic acid with appropriate personal protective equipment, including a dust mask (type N95 US recommended), eyeshields, and gloves. Ensure adequate ventilation and avoid breathing dust. It is classified as causing skin irritation, serious eye irritation, and respiratory irritation.
Is 2,4-Difluorophenylacetic acid available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 2,4-Difluorophenylacetic acid, adhering to all necessary export regulations.
How can I request a quote or sample for 2,4-Difluorophenylacetic acid?
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To request a quote or sample, please contact our sales team via the website or direct inquiry channels, providing your specific requirements and shipping details.
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