2,4-Difluoronitrobenzene
2,4-Difluoronitrobenzene (CAS 446-35-5), a fluorinated aromatic compound with the molecular formula F₂C₆H₃NO₂, is a key building block in organic synthesis. Exhibiting a density of 1.451 g/mL and a boiling point of 203-204 °C, this chemical serves as a versatile intermediate. It is primarily utilised in the synthesis of complex organic molecules, including specialised sulfonic acids and heterocyclic compounds, demonstrating its importance in advanced chemical research and development.
- IUPAC
- 2,4-Difluoro-1-nitrobenzene
- Synonyms
- F2C6H3NO22,4-Difluoro-1-nitrobenzene
Synthesis of 2,4-difluoro-5-nitrobenzenesulfonic acid
2,4-Difluoronitrobenzene is employed as a precursor in the sulfonation reaction to produce 2,4-difluoro-5-nitrobenzenesulfonic acid, a specialised chemical intermediate.
Intermediate in Pharmaceutical Synthesis
This compound has been utilised in the synthetic routes for complex molecules, such as the alkaloid (±)-horsfiline, highlighting its role in medicinal chemistry research.
Preparation of Benzimidazole Derivatives
It serves as a building block in the development of resin-bound 2-arylaminobenzimidazoles, contributing to the synthesis of novel heterocyclic compounds.
| Molecular weight | 159.09 |
|---|---|
| Linear formula | F2C6H3NO2 |
| Assay | 99% |
| Boiling point | 203-204 °C(lit.) |
| Density | 1.451 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.511(lit.) |
| Vapour density | >1 (vs air) |
| Melting point | 9-10 °C(lit.) |
| Application | 2,4-Difluoronitrobenzene has been used in the synthesis of:• 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction1• (±)-horsfiline2• resin-bound 2-arylaminobenzimidazoles3 |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 91 °C / 195.8 °F |
| Transport (UN / ADR) | UN 2810 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-36/37/38 |
| Safety statements (S) | 26-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,4-Difluoronitrobenzene used for?
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2,4-Difluoronitrobenzene is primarily used as a building block in organic synthesis, particularly for creating fluorinated intermediates, sulfonic acids, and heterocyclic compounds in research and development settings.
What is the CAS number and molecular formula for 2,4-Difluoronitrobenzene?
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The CAS number for 2,4-Difluoronitrobenzene is 446-35-5, and its molecular formula is F₂C₆H₃NO₂. Its linear formula is also noted as F₂C₆H₃NO₂.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,4-Difluoronitrobenzene with an assay of 99%. We do not represent this product as USP, BP, EP, or other pharmacopoeial grades unless explicitly stated.
How should 2,4-Difluoronitrobenzene be handled safely?
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2,4-Difluoronitrobenzene is classified as dangerous. It is toxic if swallowed and causes skin and eye irritation, and may cause respiratory irritation. Appropriate personal protective equipment, including eyeshields, face shields, gloves, and suitable respiratory protection, is essential during handling. Refer to the Safety Data Sheet for comprehensive guidance.
How is 2,4-Difluoronitrobenzene packed, shipped, and exported?
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Tech Serve Solutions securely packs and exports 2,4-Difluoronitrobenzene in compliance with international shipping regulations for hazardous materials, including UN 2810 classification. We cater to global research and industrial needs.
How can I request a quote or sample for 2,4-Difluoronitrobenzene?
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To request a quote or sample of 2,4-Difluoronitrobenzene, please contact our sales department through the website or by phone. Our team will assist you with your specific requirements.
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