2,4-Difluorophenol
2,4-Difluorophenol (CAS: 367-27-1), with the molecular formula F<sub>2</sub>C<sub>6</sub>H<sub>3</sub>OH and a molecular weight of 130.09 g/mol, is a key fluorinated organic building block. This compound is primarily utilised in chemical synthesis, particularly in the development of novel pharmaceuticals and advanced materials. Its unique difluorinated phenolic structure makes it a valuable intermediate for introducing fluorine atoms into complex organic molecules.
- Synonyms
- F2C6H3OH2,4-Difluorinephenol
Synthesis of Advanced Fluorinated Compounds
2,4-Difluorophenol serves as a critical starting material in organic synthesis for creating complex fluorinated molecules. Its structure is amenable to various coupling and derivatisation reactions.
Intermediate in Pharmaceutical Research
This compound has been employed as a reagent in the synthesis of potential pharmaceutical agents. For example, it was used in the preparation of 4,6-difluoro-5,7-dihydroxytryptamine.
Development of Fluorescent Dyes
2,4-Difluorophenol is a precursor in the synthesis of specialised fluorinated fluorescent dyes, such as 3-carboxy-6,8-difluoro-7-hydroxycoumarin (Pacific Blue), used in various analytical and imaging applications.
| Molecular weight | 130.09 |
|---|---|
| Linear formula | F2C6H3OH |
| Assay | 99% |
| Boiling point | 52-53 °C/19 mmHg(lit.) |
| Density | 1.362 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.486(lit.) |
| Application | 2,4-Difluorophenol has been used:• as starting reagent during the synthesis of 4,6-difluoro-5,7-dihydroxytryptamine1• in the synthesis of 3-carboxy-6,8-difluoro-7-hydroxycoumarin (Pacific Blue), fluorinated fluorescent dye2 |
| Melting point | 22.4 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H318Causes serious eye damage
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 57 °C / 134.6 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-37/38-41 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,4-Difluorophenol used for?
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2,4-Difluorophenol is primarily used as a building block in chemical synthesis, including the preparation of pharmaceutical intermediates and fluorinated fluorescent dyes.
What is the CAS number and formula for 2,4-Difluorophenol?
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The CAS number for 2,4-Difluorophenol is 367-27-1, and its linear formula is F<sub>2</sub>C<sub>6</sub>H<sub>3</sub>OH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,4-Difluorophenol with an assay of 99%. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated in the product specifications.
How should 2,4-Difluorophenol be handled safely?
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2,4-Difluorophenol is classified as a Danger product. Hazards include being harmful if swallowed, in contact with skin, or if inhaled, and causes skin irritation, serious eye damage, and respiratory irritation. Always use appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves, in a well-ventilated area.
How is 2,4-Difluorophenol typically packed and shipped?
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As a specialist global supplier and exporter since 1998, Tech Serve Solutions ensures that all chemicals are packed and shipped in compliance with international regulations for hazardous materials.
How can I request a quote or sample for 2,4-Difluorophenol?
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To request a quote or sample, please use the 'Request Quote' or 'Request Sample' buttons on the product page, or contact our sales team directly with your requirements.
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