2,4-Difluoroiodobenzene
2,4-Difluoroiodobenzene (CAS: 2265-93-2), with the molecular formula F₂C₆H₃I and a molecular weight of 239.99 g/mol, is a fluorinated aryl building block. This compound serves as a valuable intermediate in organic synthesis, particularly in the development of pharmaceuticals and advanced materials. Its specific halogenation pattern makes it useful for introducing difluorophenyl moieties into complex molecular structures through various coupling reactions.
- IUPAC
- 2,4-Difluoro-1-iodobenzene
- Synonyms
- F2C6H3I2,4-Difluoro-1-iodobenzene
Pharmaceutical Intermediate
2,4-Difluoroiodobenzene is utilised in the synthesis of active pharmaceutical ingredients (APIs). Its structure allows for the precise incorporation of a difluorinated phenyl ring, a common motif in modern drug discovery for modulating pharmacokinetic and pharmacodynamic properties.
Agrochemical Synthesis
The compound finds application in the development of novel agrochemicals. The presence of fluorine atoms can enhance the efficacy and metabolic stability of pesticides and herbicides.
Materials Science
It is employed as a building block in the creation of advanced materials, including liquid crystals and polymers. The unique electronic properties imparted by the fluorine and iodine substituents are advantageous in tuning material characteristics.
Organic Synthesis Reagent
As a versatile aryl halide, it participates in a range of cross-coupling reactions, such as Suzuki, Stille, and Sonogashira couplings, enabling the formation of new carbon-carbon and carbon-heteroatom bonds.
| Molecular weight | 239.99 |
|---|---|
| Linear formula | F2C6H3I |
| Assay | 98% |
| Boiling point | 175-176 °C(lit.) |
| Density | 2.006 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.557(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 68 °C / 154.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,4-Difluoroiodobenzene used for?
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2,4-Difluoroiodobenzene is primarily used as a building block in organic synthesis, particularly for the development of pharmaceuticals, agrochemicals, and advanced materials where the introduction of a 2,4-difluorophenyl group is desired.
What are the CAS number and chemical formula for 2,4-Difluoroiodobenzene?
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The CAS number for 2,4-Difluoroiodobenzene is 2265-93-2, and its linear formula is F₂C₆H₃I.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,4-Difluoroiodobenzene with an assay of 98%. This product is not classified as USP, BP, or EP grade.
How should 2,4-Difluoroiodobenzene be handled safely?
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Handle 2,4-Difluoroiodobenzene with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator (e.g., type ABEK EN14387 filter), in a well-ventilated area. It is classified as a warning substance, causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335).
Is 2,4-Difluoroiodobenzene a controlled substance?
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The provided data does not indicate that 2,4-Difluoroiodobenzene is a controlled substance.
How is 2,4-Difluoroiodobenzene shipped?
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2,4-Difluoroiodobenzene is packed and shipped according to standard chemical handling procedures, adhering to all relevant transport regulations.
How can I request a quote or sample for 2,4-Difluoroiodobenzene?
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To request a quote or sample of 2,4-Difluoroiodobenzene, please contact the Tech Serve Solutions sales team through our website or by phone.
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