2,4-Difluorobenzoyl chloride
2,4-Difluorobenzoyl chloride (CAS: 72482-64-5) is a fluorinated organic building block with the molecular formula F2C6H3COCl and a molecular weight of 176.55 g/mol. This acid halide serves as a key intermediate in organic synthesis, particularly in the creation of complex fluorinated molecules. It is valued for its reactivity in acylations, enabling the introduction of the 2,4-difluorobenzoyl moiety into various organic structures. TSS supplies this reagent with an assay of 98% for research and chemical synthesis applications.
- Synonyms
- F2C6H3COCl2,4-Difluorobenzoic acid chloride
Synthesis of Fluorinated Esters
2,4-Difluorobenzoyl chloride can be reacted with alcohols to form 2,4-difluorobenzoate esters. These esters may serve as intermediates in the synthesis of pharmaceuticals or agrochemicals, leveraging the unique properties conferred by the difluorophenyl group.
Acylating Agent in Organic Synthesis
As a reactive acid chloride, it is employed to introduce the 2,4-difluorobenzoyl group onto nucleophilic substrates, including amines and phenols. This process is fundamental in building more complex organic frameworks containing fluorinated aromatic rings.
Precursor for Heterocyclic Compounds
The compound can be utilised in cyclisation reactions to form fluorinated heterocyclic systems. Such structures are often explored for their potential biological activities in drug discovery programmes.
| Molecular weight | 176.55 |
|---|---|
| Linear formula | F2C6H3COCl |
| Assay | 98% |
| Density | 1.437 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5157(lit.) |
| Application | 2,4-Difluorobenzoyl chloride was used in the synthesis of 3-oxocyclohex-1-enyl 2,4-difluorobenzoate1. |
Hazard statements
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 82 °C / 179.6 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-36/37 |
| Safety statements (S) | 23-26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,4-Difluorobenzoyl chloride used for?
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2,4-Difluorobenzoyl chloride is primarily used as a building block and acylating agent in organic synthesis for the preparation of fluorinated organic compounds, including esters and heterocycles.
What is the CAS number and chemical formula for 2,4-Difluorobenzoyl chloride?
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The CAS number is 72482-64-5 and the linear formula is F2C6H3COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,4-Difluorobenzoyl chloride with a minimum assay of 98%. This product is intended for laboratory and chemical synthesis use and is not represented as USP, BP, or EP grade.
How should 2,4-Difluorobenzoyl chloride be handled safely?
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2,4-Difluorobenzoyl chloride is a corrosive substance that can cause severe skin burns and eye damage, and may cause respiratory irritation. Handle with appropriate personal protective equipment including gloves, eye protection, and respiratory protection in a well-ventilated area. Refer to the Safety Data Sheet for detailed handling procedures.
How is this chemical packed, shipped, and exported?
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This chemical is packed according to industry standards for hazardous materials, such as UN 3265, Class 8, PG II. We export globally, adhering to all relevant international shipping regulations.
How can I request a sample or quote for 2,4-Difluorobenzoyl chloride?
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Please contact our sales team via the website or email to request a sample or obtain a quotation for 2,4-Difluorobenzoyl chloride.
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