2,4-Difluorobenzenesulfonyl chloride
2,4-Difluorobenzenesulfonyl chloride (CAS: 13918-92-8), with the linear formula F2C6H3SO2Cl and a molecular weight of 212.60 g/mol, is a crucial organic fluorinated building block. It serves as a valuable intermediate in chemical synthesis, particularly for the introduction of the 2,4-difluorobenzenesulfonyl moiety into various organic molecules. Its properties make it suitable for diverse research and industrial applications.
- Synonyms
- F2C6H3SO2Cl

Organic Synthesis Intermediate
This compound acts as a key intermediate in the synthesis of complex organic molecules. It is frequently employed in reactions where the introduction of a fluorinated aryl sulfonyl group is required, facilitating the creation of novel chemical entities.
Pharmaceutical Research
As a fluorinated building block, 2,4-Difluorobenzenesulfonyl chloride is utilised in the development of new pharmaceutical candidates. The presence of fluorine atoms can significantly influence the pharmacokinetic and pharmacodynamic properties of drug molecules.
Agrochemical Development
The compound may find application in the synthesis of novel agrochemicals, where fluorinated structures are often explored for enhanced efficacy and stability.
Material Science
It can serve as a precursor in the development of specialised materials, where its unique structural features might impart desirable properties.
| Molecular weight | 212.60 |
|---|---|
| Linear formula | F2C6H3SO2Cl |
| Assay | 97% |
| Boiling point | 236-237 °C(lit.) |
| Density | 1.581 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.518(lit.) |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 110 °C / 230 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,4-Difluorobenzenesulfonyl chloride used for?
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2,4-Difluorobenzenesulfonyl chloride is primarily used as an intermediate in organic synthesis, particularly for introducing the 2,4-difluorobenzenesulfonyl group in the development of pharmaceuticals, agrochemicals, and other fine chemicals.
What is the CAS number and formula for 2,4-Difluorobenzenesulfonyl chloride?
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The CAS number is 13918-92-8, and its linear formula is F2C6H3SO2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,4-Difluorobenzenesulfonyl chloride with a minimum assay of 97%. This product is supplied for research and industrial use and is not intended for pharmaceutical, food, or any other regulated application unless explicitly stated otherwise.
How should 2,4-Difluorobenzenesulfonyl chloride be handled safely?
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2,4-Difluorobenzenesulfonyl chloride is a corrosive substance that can cause severe skin burns and eye damage (H314). Handle with extreme care, using appropriate personal protective equipment including gloves, goggles, and a face shield. Work in a well-ventilated area or use a suitable respirator. Refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.
How is this chemical packed and exported?
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2,4-Difluorobenzenesulfonyl chloride is packed according to international shipping regulations for hazardous materials (UN 3265, Class 8, PG II). Tech Serve Solutions is experienced in exporting chemicals globally, ensuring compliance with all relevant transport and customs requirements.
How can I request a sample or quote for 2,4-Difluorobenzenesulfonyl chloride?
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To request a sample or a quotation, please contact our sales department through the website or by calling us directly. Please specify the quantity required and your delivery location.
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