2,4-Difluorophenylboronic acid pinacol ester
2,4-Difluorophenylboronic acid pinacol ester (CAS 288101-48-4) is an organoboron compound with the molecular formula C12H15BF2O2. This white to off-white solid serves as a valuable building block in organic synthesis. Its primary application lies in cross-coupling reactions, particularly Suzuki-Miyaura couplings, enabling the introduction of the 2,4-difluorophenyl moiety into complex molecular architectures for research and development.
- IUPAC
- 2-(2,4-Difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
- Synonyms
- 2-(2,4-Difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Suzuki-Miyaura Coupling Reagent
This pinacol ester is widely employed as a coupling partner in Suzuki-Miyaura reactions. It facilitates the formation of carbon-carbon bonds by reacting with aryl or vinyl halides and triflates, allowing for the synthesis of diverse biaryl compounds.
Pharmaceutical Intermediate Synthesis
The 2,4-difluorophenyl group is a common structural element in many pharmacologically active compounds. This reagent is therefore crucial for the synthesis of advanced intermediates in drug discovery and development pipelines.
Materials Science Research
Incorporation of fluorinated aromatic rings can modulate the electronic and physical properties of organic materials. 2,4-Difluorophenylboronic acid pinacol ester is utilized in the creation of novel organic electronic materials and polymers.
Agrochemical Development
Fluorinated motifs are also found in various agrochemicals. This boronate ester can be employed in the synthetic routes towards new pesticides, herbicides, and fungicides.
| Molecular weight | 240.05 |
|---|---|
| Empirical formula | C12H15BF2O2 |
| Assay | 97% |
| Storage temperature | 2-8°C |
| Melting point | 41-44 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 108 °C / 226.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,4-Difluorophenylboronic acid pinacol ester used for?
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This compound is primarily used as a reagent in Suzuki-Miyaura cross-coupling reactions for the synthesis of complex organic molecules, particularly those containing the 2,4-difluorophenyl moiety, finding applications in pharmaceuticals, agrochemicals, and materials science.
What are the CAS number and molecular formula?
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The CAS number is 288101-48-4, and the molecular formula is C12H15BF2O2. The empirical formula (Hill notation) is also C12H15BF2O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,4-Difluorophenylboronic acid pinacol ester with an assay of 97%. This is a technical grade suitable for research and general chemical synthesis; TSS does not represent it as USP, BP, or EP grade.
How should 2,4-Difluorophenylboronic acid pinacol ester be handled safely?
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This compound is a warning irritant (H315, H319, H335). Handle with a dust mask (type N95 US recommended), eyeshields, and gloves in a well-ventilated area. Avoid breathing dust. In case of contact, rinse eyes thoroughly with water and seek medical advice if irritation persists.
How is this product shipped and exported?
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Tech Serve Solutions is an experienced global supplier and exporter of fine chemicals. Products are carefully packaged according to international shipping regulations and can be exported worldwide. Please contact us for specific export inquiries.
How can I request a quote or sample?
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To request a quote or a sample of 2,4-Difluorophenylboronic acid pinacol ester, please use the contact form on our website or reach out to our sales team directly with your requirements.
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