2,4-Difluorophenylboronic acid
2,4-Difluorophenylboronic acid (CAS: 144025-03-6) is an organoboron compound with the molecular formula F₂C₆H₃B(OH)₂ and a molecular weight of 157.91 g/mol. This white to off-white solid is a key intermediate in organic synthesis, primarily recognised for its utility in palladium-catalysed cross-coupling reactions, such as the Suzuki-Miyaura coupling. It serves as a valuable building block for constructing complex organic molecules in various research and development settings.
- IUPAC
- 2,4-Difluorobenzeneboronic acid
- Synonyms
- F2C6H3B(OH)22,4-Difluorobenzeneboronic acid
Suzuki Coupling Reagent
2,4-Difluorophenylboronic acid is widely employed as a coupling partner in Suzuki-Miyaura reactions. This facilitates the formation of carbon-carbon bonds, enabling the synthesis of biaryl compounds and other complex organic structures.
Organic Synthesis Intermediate
It serves as a versatile building block in the synthesis of diverse organic molecules. Its difluorinated phenyl moiety can be incorporated into target structures for applications in medicinal chemistry and materials science.
Research and Development
This compound is frequently used in academic and industrial research laboratories for the development of new synthetic methodologies and the exploration of novel chemical entities.
| Molecular weight | 157.91 |
|---|---|
| Linear formula | F2C6H3B(OH)2 |
| Application | Widely used in Suzuki coupling.6,7 |
| Melting point | 247-250 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,4-Difluorophenylboronic acid primarily used for?
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2,4-Difluorophenylboronic acid is primarily used as a reagent in Suzuki coupling reactions for the synthesis of biaryl compounds and as a general intermediate in organic synthesis.
What is the CAS number and chemical formula for 2,4-Difluorophenylboronic acid?
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The CAS number is 144025-03-6 and the linear chemical formula is F₂C₆H₃B(OH)₂.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,4-Difluorophenylboronic acid in a purity suitable for research and chemical synthesis. We do not represent this product as USP, BP, or EP grade.
How should 2,4-Difluorophenylboronic acid be handled safely?
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2,4-Difluorophenylboronic acid is classified as a Warning substance, with hazards including skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (type N95), eyeshields, and gloves, should be used. Handle in a well-ventilated area or fume hood.
How is 2,4-Difluorophenylboronic acid packed and shipped?
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Products are carefully packed to ensure safe transit and compliance with international shipping regulations. TSS is a global supplier and exporter of fine chemicals.
How can I request a sample or quote for 2,4-Difluorophenylboronic acid?
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Please use the 'Request a Quote' or 'Sample Request' form on our website, providing the product name and CAS number (144025-03-6).
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