2-(Trifluoromethoxy)phenylboronic acid

CAS 175676-65-0F3CO(C6H4)B(OH)2Chemical Synthesis

2-(Trifluoromethoxy)phenylboronic acid (CAS: 175676-65-0), with the molecular formula F3CO(C6H4)B(OH)2 and a molecular weight of 205.93 g/mol, is a key aryl boronic acid derivative. It serves as a crucial building block in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions. This compound is essential for preparing complex molecules used in pharmaceutical research and the development of novel therapeutic agents.

IUPAC: 2-(Trifluoromethoxy)benzeneboronic acid

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2-(Trifluoromethoxy)phenylboronic acid (F3CO(C6H4)B(OH)2) — chemical structure, CAS 175676-65-0; Chemistry, fine chemical supplied by Tech Serve Solutions

Aryl Boronic AcidsBoronic AcidsChemical Synthesis

01 /Applications

Suzuki-Miyaura Cross-Coupling Reactions

This compound is a versatile reagent for Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds for the synthesis of biaryl compounds.

Phosphodiesterase 10A Inhibitors

It is utilized in the preparation of imidazo[1,5-a]pyrido[3,2-e]pyrazines and imidazo[1,5-a]quinoxalines, which are investigated as potential orally active phosphodiesterase 10A inhibitors.

Transient Receptor Potential Melastatin 8 Antagonists

The boronic acid is a reactant in the synthesis of 3-(5-arylbenzimidazol-2-yl)-1-oxa-2-azaspiro[4.5]decenes, which are explored as transient receptor potential melastatin 8 antagonists.

Sodium Channel Blockers

This compound facilitates the preparation of biaryl pyrazole carboxamides and biaryl oxazoles, imidazoles, and thiazoles, investigated as sodium channel blockers for neuropathic pain treatment.

02 /Properties

Molecular weight	205.93
Linear formula	F3CO(C6H4)B(OH)2
Application	Reactant for:• Preparation of imidazo[1,5-a]pyrido[3,2-e]pyrazines and imidazo[1,5-a]quinoxalines as orally active phosphodiesterase 10A inhibitors1• Suzuki-Miyaura cross-coupling reactions2• Preparation of 3-(5-arylbenzimidazol-2-yl)-1-oxa-2-azaspiro[4.5]decenes as transient receptor potential melastatin 8 antagonists3• Preparation of biaryl pyrazole carboxamides as sodium channel blockers for treatment of neuropathic pain4• Preparation of biaryl oxazoles, imidazoles and thiazoles via condensations as sodium channel blockers and CYP inhibitors for treatment of neuropathic pain5

03 /Identifiers & registry

CAS number

175676-65-0

MDL number

MFCD01320763

PubChem substance

24885779

04 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

05 /Frequently asked questions

What is 2-(Trifluoromethoxy)phenylboronic acid used for?

2-(Trifluoromethoxy)phenylboronic acid is used as a reactant in organic synthesis, notably for Suzuki-Miyaura cross-coupling reactions, and in the preparation of various biologically active compounds including phosphodiesterase 10A inhibitors, TRPM8 antagonists, and sodium channel blockers.

What is the CAS number and molecular formula for this compound?

The CAS number is 175676-65-0, and the molecular formula is F3CO(C6H4)B(OH)2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this chemical for research and development purposes. The specific grade and purity available are detailed in the product specifications. We do not represent this product as meeting USP, BP, or EP pharmacopoeial standards.

What are the safety and handling considerations for 2-(Trifluoromethoxy)phenylboronic acid?

This compound has a WGK Germany rating of 3, indicating it is hazardous to water. Handle with appropriate personal protective equipment in a well-ventilated area. Consult the Safety Data Sheet (SDS) for comprehensive hazard information and handling procedures.

How is this chemical packed and shipped?

Tech Serve Solutions exports fine chemicals, pharmaceutical intermediates, and laboratory reagents globally. Packaging and shipping are handled in compliance with international regulations to ensure safe transit.