1-(4-Fluorophenyl)piperazine dihydrochloride
1-(4-Fluorophenyl)piperazine dihydrochloride (CAS 64090-19-3; C10H13FN2·2HCl; molar mass 253.14 g/mol) is the dihydrochloride salt of a fluorinated arylpiperazine. Supplied as a crystalline solid at 98% assay, it serves principally as a heterocyclic building block and synthetic intermediate in chemical research and pharmaceutical synthesis. The 4-fluorophenyl substituent and secondary piperazine nitrogen make it a versatile scaffold for N-functionalisation and onward derivatisation.
- Synonyms
- 1-(4-Fluorophenyl)piperazine dihydrochloride4-Fluorophenylpiperazine dihydrochloride1-(4-Fluorophenyl)piperazine 2HClp-Fluorophenylpiperazine dihydrochloridepFPP dihydrochloride
Heterocyclic building block
Used as a piperazine building block in chemical synthesis, where the free secondary amine provides a convenient handle for N-alkylation, N-acylation and reductive amination. The salt form offers improved handling and crystallinity over the free base.
Pharmaceutical intermediate
Arylpiperazines of this type are common intermediates in medicinal chemistry programmes. The 4-fluorophenyl group is frequently incorporated to tune the electronic and metabolic properties of candidate molecules.
Research and discovery chemistry
Employed at laboratory scale for the preparation of fluorinated piperazine derivatives and analogue libraries in early-stage discovery and structure-activity studies.
Reference and analytical use
Its defined identity (CAS 64090-19-3, MDL MFCD00012765) and consistent purity make it suitable as a characterised reference material for method development and analytical comparison.
| Molecular weight | 253.14 |
|---|---|
| Empirical formula | C10H13FN2 · 2HCl |
| Assay | 98% |
| Melting point | 231-234 °C(lit.) |
Hazard statements
- H301Toxic if swallowed
- H311Toxic in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H331Toxic if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 23/24/25-36/37/38 |
| Safety statements (S) | 22-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(4-Fluorophenyl)piperazine dihydrochloride used for?
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It is used mainly as a heterocyclic building block and synthetic intermediate in chemical research and pharmaceutical synthesis. The reactive secondary piperazine nitrogen allows ready N-functionalisation, making the 4-fluorophenyl scaffold useful for preparing fluorinated piperazine derivatives.
What is the CAS number and molecular formula of 1-(4-Fluorophenyl)piperazine dihydrochloride?
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The CAS number is 64090-19-3 and the molecular formula is C10H13FN2·2HCl, corresponding to a molecular weight of 253.14 g/mol. Its MDL number is MFCD00012765 and PubChem substance ID is 24858177.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product at a typical assay of 98% as a research/technical-grade material. We do not represent it as USP, BP or EP pharmacopoeia grade. A certificate of analysis can be provided with each consignment on request.
What are the safety and handling hazards of this compound?
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It is classified Danger (GHS06). It is toxic if swallowed, in contact with skin or if inhaled (H301, H311, H331) and causes skin and eye irritation and may cause respiratory irritation (H315, H319, H335). Handle with eye and face protection, gloves and a type P2 respirator, avoid all routes of exposure, and consult the SDS before use.
How is 1-(4-Fluorophenyl)piperazine dihydrochloride packed, shipped and exported?
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It is packed in sealed, labelled containers appropriate to the order quantity and shipped with full documentation. For transport it is classified as UN 2811, Class 6.1 (toxic solid), Packing Group II, and is consigned in compliance with the applicable dangerous-goods regulations to destinations worldwide.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and packing, and we will respond with availability, lead time and a formal quotation. Samples can be arranged subject to regulatory and dangerous-goods requirements.
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