1-(4-Hydroxyphenyl)piperazine
1-(4-Hydroxyphenyl)piperazine (CAS 56621-48-8) is a crystalline heterocyclic building block with the molecular formula C10H14N2O and a molecular weight of 178.23 g/mol. Also known as 4-piperazinophenol, it combines a piperazine ring with a para-hydroxyphenyl group, giving both a secondary amine and a phenolic handle for onward functionalisation. It is used principally in pharmaceutical and fine-chemical synthesis as an intermediate for piperazine-containing molecules. Tech Serve Solutions supplies it at an assay of not less than 98.0 percent.
- IUPAC
- 4-Piperazinophenol
- Synonyms
- 1-(4-Hydroxyphenyl)piperazine4-Piperazinophenol4-(Piperazin-1-yl)phenol4-(1-Piperazinyl)phenolCAS 56621-48-8
Pharmaceutical intermediate
Serves as a building block in the synthesis of piperazine-based pharmaceutical candidates and intermediates. The free piperazine nitrogen and phenolic group offer two reactive sites for amide, alkylation and ether chemistry.
Heterocyclic building block
Used in medicinal and process chemistry to introduce a hydroxyphenyl-piperazine motif into larger structures. It is a versatile scaffold for fragment-based and analogue synthesis.
Phenol functionalisation
The para-hydroxy group can be etherified, acylated or used in coupling reactions, enabling the preparation of substituted aryl-piperazine derivatives.
Research and discovery chemistry
Employed as a reference and starting material in laboratory-scale exploratory synthesis where a defined arylpiperazine fragment is required.
| Molecular weight | 178.23 |
|---|---|
| Empirical formula | C10H14N2O |
| Assay | ≥98.0% (NT) |
| Melting point | 220-225 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(4-Hydroxyphenyl)piperazine used for?
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It is used mainly as a synthetic intermediate and heterocyclic building block in pharmaceutical and fine-chemical synthesis. Its piperazine nitrogen and phenolic hydroxyl provide two reactive sites for constructing arylpiperazine derivatives and more complex target molecules.
What is the CAS number and molecular formula of 1-(4-Hydroxyphenyl)piperazine?
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The CAS number is 56621-48-8 and the molecular formula is C10H14N2O, with a molecular weight of 178.23 g/mol. The EC number is 260-289-6 and the MDL number is MFCD00066156. It is also known as 4-piperazinophenol.
What grade and purity does Tech Serve Solutions supply?
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We supply 1-(4-Hydroxyphenyl)piperazine at an assay of not less than 98.0 percent, as a research and technical grade reagent. We do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis can be provided with each batch.
What are the safety and handling requirements?
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Under GHS this material carries the pictogram GHS07 and signal word Warning, with hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Avoid dust formation, use an N95-type dust mask, eye protection and gloves (P261, P305+P351+P338), and consult the SDS before use. It is assigned WGK 3 (highly hazardous to water) in Germany, so prevent release to the environment.
How is 1-(4-Hydroxyphenyl)piperazine packed, shipped and exported?
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It is supplied as a solid in tightly sealed containers sized from research quantities to bulk, with full labelling and a certificate of analysis. As a long-standing global supplier and exporter, Tech Serve Solutions handles documentation and compliant international shipping; packaging and quantities can be tailored to your requirement.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and destination, and our team will respond with availability, lead time and export details. Samples can be arranged for evaluation where appropriate.
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