1-(4-Methoxybenzyl)-6-((trimethylsilyl)ethynyl)-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one
1-(4-Methoxybenzyl)-6-((trimethylsilyl)ethynyl)-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one (CAS 1198425-56-7) is an organosilicon heterocyclic building block with the molecular formula C20H22N2O3Si and a molar mass of 366.49 g/mol. It pairs a fused pyrido[2,3-b][1,4]oxazinone core with a 4-methoxybenzyl (PMB) N-protecting group and a trimethylsilyl-protected terminal alkyne. Tech Serve Solutions supplies it as a research-grade intermediate for medicinal and discovery chemistry.
- Synonyms
- 1-(4-Methoxybenzyl)-6-((trimethylsilyl)ethynyl)-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one1-(4-methoxybenzyl)-6-[2-(trimethylsilyl)ethynyl]-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one1-[(4-methoxyphenyl)methyl]-6-[2-(trimethylsilyl)ethynyl]pyrido[2,3-b][1,4]oxazin-2(3H)-oneCAS 1198425-56-7C20H22N2O3Si
![1-(4-Methoxybenzyl)-6-((trimethylsilyl)ethynyl)-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one (C20H22N2O3Si) — chemical structure, CAS 1198425-56-7; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F1198425-56-7.png&w=3840&q=75)
Heterocyclic building block
The fused pyrido[2,3-b][1,4]oxazin-2(3H)-one scaffold serves as a building block in medicinal and discovery chemistry, providing a nitrogen- and oxygen-rich bicyclic core for the assembly of more complex molecules.
Masked terminal alkyne for cross-coupling
The trimethylsilyl (TMS) group protects a terminal alkyne that can be unmasked under mild basic conditions. The resulting free alkyne is a handle for Sonogashira coupling, click (CuAAC) chemistry and other alkyne-based bond formation.
Protected synthetic intermediate
The 4-methoxybenzyl (PMB) group is a removable nitrogen-protecting group, allowing the ring nitrogen to be selectively revealed at a later stage of a multi-step synthesis.
Organosilicon reagent
As an organosilicon compound, it is used where a silyl-protected alkyne is required for controlled, stepwise functionalisation of the heteroaromatic framework.
| Molecular weight | 366.49 |
|---|---|
| Empirical formula | C20H22N2O3Si |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(4-Methoxybenzyl)-6-((trimethylsilyl)ethynyl)-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one used for?
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It is used as a research-grade synthetic building block. The bicyclic pyrido-oxazinone core, the removable 4-methoxybenzyl (PMB) nitrogen-protecting group and the trimethylsilyl-protected terminal alkyne make it a versatile intermediate for medicinal and discovery chemistry, including Sonogashira and click-type couplings after desilylation.
What is the CAS number and molecular formula of 1-(4-Methoxybenzyl)-6-((trimethylsilyl)ethynyl)-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one?
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The CAS number is 1198425-56-7. The empirical formula is C20H22N2O3Si (Hill notation) with a molecular weight of 366.49 g/mol.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound as a research/technical-grade building block for synthetic and laboratory use. We do not represent it as USP, BP or EP pharmacopoeial grade. A current Certificate of Analysis stating the actual assay for the available lot is provided with each order on request.
How should this compound be handled and stored?
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Treat it as a research chemical of not fully characterised hazard: handle only in a properly equipped laboratory using gloves, eye protection and a fume hood, and avoid dust, skin contact and inhalation. Keep tightly closed, dry and away from heat or ignition sources. Always consult the Safety Data Sheet supplied with the consignment before use.
How is 1-(4-Methoxybenzyl)-6-((trimethylsilyl)ethynyl)-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one packed, shipped and exported?
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It is packed in laboratory-appropriate quantities in sealed, suitably labelled containers with secure secondary packaging for transport. As a specialist exporter since 1998, Tech Serve Solutions ships worldwide with full documentation, including the Safety Data Sheet and Certificate of Analysis, in line with applicable transport regulations.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity and delivery destination, quoting CAS 1198425-56-7, and our team will confirm availability, current specification, lead time and export terms.
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