1-(4-Iodophenyl)piperazine hydrochloride
1-(4-Iodophenyl)piperazine hydrochloride (CAS 624726-35-8) is the hydrochloride salt of an aryl-substituted piperazine, with molecular formula IC6H4C4H9N2 · HCl and a molar mass of 324.59 g/mol. Supplied as a research-grade building block of around 95% assay, it serves as a heterocyclic intermediate in chemical synthesis and medicinal-chemistry research. The combination of a reactive aryl iodide and a free piperazine N-H makes it a versatile scaffold for cross-coupling and acylation. Tech Serve Solutions supplies and exports it worldwide.
- Synonyms
- 1-(4-Iodophenyl)piperazine hydrochloride1-(4-Iodophenyl)piperazine HCl4-(4-Iodophenyl)piperazine hydrochloride1-(4-iodophenyl)piperazine monohydrochlorideCAS 624726-35-8MFCD04119724
Heterocyclic building block
Used as a piperazine-based scaffold in chemical synthesis. The free secondary amine on the piperazine ring allows alkylation, acylation and sulfonylation to assemble more elaborate molecules.
Aryl iodide for cross-coupling
The para-iodo aryl group is a reactive handle for transition-metal-catalysed cross-coupling reactions such as Suzuki, Sonogashira, Buchwald-Hartwig and related carbon-carbon and carbon-heteroatom bond formations.
Medicinal-chemistry intermediate
Aryl-piperazine motifs are common pharmacophores in drug-discovery programmes. This compound is used as an intermediate and exploratory building block in pharmaceutical and medicinal-chemistry research.
Laboratory research reagent
Functions as a reference building block in method development and structure-activity studies. The salt form aids handling, weighing and storage relative to the free base.
| Molecular weight | 324.59 |
|---|---|
| Linear formula | IC6H4C4H9N2 · HCl |
| Assay | 95% |
| Melting point | 177-181 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-37/38-41 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(4-Iodophenyl)piperazine hydrochloride used for?
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It is used mainly as a research-grade synthetic building block and intermediate. The reactive aryl iodide and free piperazine N-H make it suitable for cross-coupling reactions and for constructing aryl-piperazine scaffolds in medicinal-chemistry and laboratory research.
What is the CAS number and molecular formula of 1-(4-Iodophenyl)piperazine hydrochloride?
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The CAS number is 624726-35-8 and the molecular formula is IC6H4C4H9N2 · HCl, corresponding to a molecular weight of 324.59 g/mol. The MDL number is MFCD04119724 and the reported melting point is 177-181 °C.
What grade and purity does Tech Serve Solutions supply?
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We supply this product as a research/technical grade material with a typical assay of around 95%. We do not represent it as USP, BP or EP pharmacopoeia grade. A certificate of analysis can be provided with each batch on request.
What are the safety and handling precautions?
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It is classified under GHS05 and GHS07 with the signal word Danger. It is harmful if swallowed (H302), causes skin irritation (H315), causes serious eye damage (H318) and may cause respiratory irritation (H335). Use gloves, eye protection and an N95-type dust mask, avoid dust generation, and consult the SDS before use.
How is 1-(4-Iodophenyl)piperazine hydrochloride packed, shipped and exported?
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It is packed as a solid in tightly sealed containers with appropriate inner protection, sized to the order from gram to bulk quantities. We export worldwide with full documentation, including a certificate of analysis and safety data sheet, and apply GHS labelling and transport requirements for the destination.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and destination, and our team will respond with availability, lead time and export documentation. Samples can be arranged where supply permits.
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