1-(4-Methoxybenzyl)piperazine
1-(4-Methoxybenzyl)piperazine (CAS 21867-69-6) is a heterocyclic piperazine building block with the molecular formula C12H18N2O and a molar mass of 206.28 g/mol. It is a low-melting solid (mp 32-36 °C) comprising a piperazine ring bearing a 4-methoxybenzyl substituent on one nitrogen. The free secondary nitrogen makes it a versatile intermediate for chemical synthesis, widely used in research and discovery chemistry. Tech Serve Solutions supplies it at 97% assay for laboratory and process applications.
- Synonyms
- 1-(4-Methoxybenzyl)piperazine1-(4-Methoxybenzyl)piperazine, 97%4-Methoxybenzylpiperazine1-(p-Methoxybenzyl)piperazine1-[(4-Methoxyphenyl)methyl]piperazineCAS 21867-69-6
Heterocyclic building block
Used as a mono-substituted piperazine scaffold in chemical synthesis, where the free secondary nitrogen provides a reactive handle for alkylation, acylation, sulfonylation and reductive amination.
Pharmaceutical and discovery intermediate
Serves as an intermediate in medicinal-chemistry and discovery programmes that exploit the N-arylmethyl piperazine motif, a recurring fragment in active-compound libraries.
Reagent for amine chemistry
The secondary amine functionality allows it to act as a nucleophile or coupling partner in the preparation of more elaborate piperazine derivatives and structure-activity studies.
Laboratory research and method development
Supplied at reagent purity for use as a reference material and starting material in synthetic, analytical and process-development laboratories.
| Molecular weight | 206.28 |
|---|---|
| Empirical formula | C12H18N2O |
| Assay | 97% |
| Melting point | 32-36 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | >110 °C / >230 °F |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(4-Methoxybenzyl)piperazine used for?
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It is used primarily as a heterocyclic building block and synthetic intermediate. The piperazine ring carries a 4-methoxybenzyl group on one nitrogen, leaving a free secondary amine that can be further functionalised, making the compound useful in chemical synthesis and medicinal-chemistry research.
What is the CAS number and molecular formula of 1-(4-Methoxybenzyl)piperazine?
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The CAS number is 21867-69-6 and the molecular formula is C12H18N2O, corresponding to a molecular weight of 206.28 g/mol. Its MDL number is MFCD01075236 and the PubChem Substance ID is 24883436.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-(4-Methoxybenzyl)piperazine at a typical assay of 97% as a research/technical-grade material. We do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis can be provided with each batch on request.
What are the safety and handling considerations?
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Under GHS it carries the signal word Warning (pictogram GHS07) with hazard statements H302 (harmful if swallowed) and H319 (causes serious eye irritation). Avoid ingestion and eye contact, wear gloves and eye protection, and use a dust mask where dust may form. If in eyes, rinse cautiously with water for several minutes and remove contact lenses if present (P305+P351+P338). It is assigned WGK 2 (water-hazard class) in Germany. Always consult the Safety Data Sheet before use.
How is 1-(4-Methoxybenzyl)piperazine packed, shipped and exported?
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It is packed in tightly sealed containers appropriate to the order quantity, with full labelling and documentation. As a low-melting solid it is handled and shipped to preserve product integrity. Tech Serve Solutions exports worldwide and can align packaging and paperwork with your destination and import requirements.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and destination, quoting the product name and CAS 21867-69-6. We will respond with availability, lead time, packaging options and a quotation, and can arrange a sample where appropriate.
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