1-(4-Fluorophenyl)piperazine
1-(4-Fluorophenyl)piperazine (CAS 2252-63-3; C10H13FN2; molar mass 180.22 g/mol) is a fluorinated heterocyclic building block in which a piperazine ring carries a 4-fluorophenyl substituent on one nitrogen. Supplied as a low-melting solid at 98% assay, it is used principally in research and fine-chemical synthesis, notably to prepare N,N-disubstituted piperazines and related intermediates. Tech Serve Solutions supplies and exports it worldwide to laboratory and synthesis customers.
- Synonyms
- 1-(4-Fluorophenyl)piperazine4-Fluorophenylpiperazine1-(4-Fluorophenyl)-piperazinepFPPCAS 2252-63-3MFCD00005960EC 218-846-6
Synthesis of N,N-disubstituted piperazines
The compound serves as a starting material for the preparation of N,N-disubstituted piperazines, with the free secondary nitrogen available for alkylation, acylation or arylation.
Fluorinated heterocyclic building block
As an aryl piperazine bearing a fluorine substituent, it is used as a building block for assembling more complex fluorinated heterocyclic scaffolds in medicinal and synthetic chemistry research.
Pharmaceutical intermediate research
The aryl piperazine motif is a recurring feature in pharmaceutical chemistry, making this reagent a useful intermediate for exploratory and route-development work.
Laboratory reagent
It is offered as a research-grade reagent for use in general organic synthesis and method development at laboratory scale.
| Molecular weight | 180.22 |
|---|---|
| Empirical formula | C10H13FN2 |
| Assay | 98% |
| Boiling point | 118-123 °C/0.1 mmHg(lit.) |
| Application | 1-(4-Fluorophenyl)piperazine was used in the synthesis of N,N-disubstituted piperazine1. |
| Melting point | 30-33 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | rat ... Chrnb2(54239) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(4-Fluorophenyl)piperazine used for?
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It is used chiefly as a building block in research and fine-chemical synthesis. A documented application is the synthesis of N,N-disubstituted piperazines, and more generally it serves as a fluorinated aryl piperazine intermediate for medicinal and synthetic chemistry.
What is the CAS number and molecular formula of 1-(4-Fluorophenyl)piperazine?
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The CAS number is 2252-63-3 and the molecular formula is C10H13FN2, with a molecular weight of 180.22 g/mol. Its MDL number is MFCD00005960 and EC number 218-846-6.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this material at a typical assay of 98% as a research/technical-grade reagent. We do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis is provided with each batch.
What are the safety and handling requirements?
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It is classified under GHS07 with the signal word Warning and hazard statements H302 (harmful if swallowed), H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Use an N95-type dust mask, gloves and eye/face protection, avoid dust formation, and consult the SDS before use. It is assigned WGK 2 (water hazard) in Germany.
How is 1-(4-Fluorophenyl)piperazine packed, shipped and exported?
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It is packed in suitable sealed containers sized to the order, with appropriate labelling and documentation including a certificate of analysis and SDS. Tech Serve Solutions handles export logistics and arranges compliant international shipping to your destination.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, grade and delivery destination. We will confirm availability, lead time and shipping options, and can arrange a sample where appropriate.
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