1-(4-Fluorophenyl)biguanide hydrochloride
1-(4-Fluorophenyl)biguanide hydrochloride (CAS 16018-83-0) is the hydrochloride salt of a 4-fluorophenyl-substituted biguanide, a nitrogen-rich guanidine building block with the molecular formula C6H4NHC(NH)NHC(NH)NH2 · HCl and a molar mass of 231.66 g/mol. Supplied as a crystalline solid, it serves chiefly as a synthetic intermediate in organic and medicinal chemistry, where the biguanide group is used to construct triazine, dihydrotriazine and related heterocyclic systems.
- Synonyms
- 1-(4-Fluorophenyl)biguanide hydrochloride4-Fluorophenylbiguanide hydrochlorideN-(4-Fluorophenyl)imidodicarbonimidic diamide hydrochloride1-(4-Fluorophenyl)biguanide HClCAS 16018-83-0
Heterocyclic synthesis
The biguanide moiety undergoes cyclocondensation to build 1,3,5-triazine, dihydrotriazine and pyrimidine ring systems. The 4-fluorophenyl substituent introduces a fixed fluorine handle that can influence the electronic character of the resulting heterocycles.
Medicinal chemistry building block
As a fluorinated arylbiguanide, it is used as an intermediate and scaffold in research aimed at biguanide- and triazine-derived compounds. Fluorine substitution is a common strategy in early-stage discovery work.
Coordination and chelation chemistry
Biguanides are well-documented multidentate nitrogen donors capable of coordinating metal ions. This compound can serve as a ligand precursor in studies of metal complexes.
Reference and laboratory reagent
With a defined assay and characteristic melting point (250-254 °C, lit.), the material is suitable for use as a reagent and characterisation reference in research laboratories.
| Molecular weight | 231.66 |
|---|---|
| Linear formula | C6H4NHC(NH)NHC(NH)NH2 · HCl |
| Assay | 97% |
| Melting point | 250-254 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(4-Fluorophenyl)biguanide hydrochloride used for?
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It is used mainly as a synthetic intermediate and building block in organic and medicinal chemistry. The biguanide group enables cyclocondensation into triazine, dihydrotriazine and pyrimidine heterocycles, and can also act as a multidentate ligand precursor in coordination chemistry.
What is the CAS number and molecular formula of 1-(4-Fluorophenyl)biguanide hydrochloride?
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Its CAS number is 16018-83-0 and its molecular formula is C6H4NHC(NH)NHC(NH)NH2 · HCl, with a molecular weight of 231.66 g/mol and MDL number MFCD00051986.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product at a typical assay of 97% as a technical/research-grade material for synthesis and laboratory use. We do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis can be provided with each batch.
What are the safety and handling requirements?
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The product is classified under GHS07 with the signal word Warning. It causes skin irritation (H315), serious eye irritation (H319) and may cause respiratory irritation (H335). Handle with gloves, eye protection and an N95-type dust mask, avoid generating dust, and work with adequate ventilation. Consult the SDS before use.
Is 1-(4-Fluorophenyl)biguanide hydrochloride a controlled substance?
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Based on the data we hold, it is not listed as a controlled or scheduled substance and is supplied as a standard research chemical. Customers remain responsible for confirming any import, export or end-use requirements in their own jurisdiction.
How is 1-(4-Fluorophenyl)biguanide hydrochloride packed, shipped and exported?
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It is packed as a solid in suitable, tightly closed containers sized to order, with full labelling and documentation. As a specialist exporter, Tech Serve Solutions arranges compliant international shipping and supplies the SDS and certificate of analysis with each consignment.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, packaging and destination, and our team will respond with availability, lead time and a formal quotation. Samples can be arranged on request, subject to availability.
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