N-Methyltrifluoroacetamide
N-Methyltrifluoroacetamide (CAS: 815-06-5) is a fluorinated organic compound with the linear formula CF3CONHCH3 and a molecular weight of 127.07 g/mol. This amide is characterised by the presence of a trifluoromethyl group and serves as a valuable building block in organic synthesis. Its applications span various chemical research and development sectors, particularly in the creation of novel compounds and intermediates.

Organic Synthesis Intermediate
N-Methyltrifluoroacetamide acts as a versatile intermediate in the synthesis of more complex organic molecules. Its trifluoromethyl group can impart unique properties to target compounds, making it useful in medicinal chemistry and materials science research.
Building Block for Fluorinated Compounds
As a readily available source of the trifluoroacetyl moiety, this compound is employed in the construction of diverse fluorinated organic structures. These structures are often sought after for their altered reactivity, stability, and biological activity profiles.
Reagent in Specialty Chemistry
It finds application in specialised chemical reactions where precise introduction of fluorinated groups is required. This can include derivatisation or the modification of existing molecular frameworks.
| Molecular weight | 127.07 |
|---|---|
| Linear formula | CF3CONHCH3 |
| Assay | ≥98.0% (GC) |
| Grade | purum |
| Boiling point | 156-157 °C(lit.) |
| Melting point | 48-51 °C49-51 °C(lit.) |


Hazard statements
- H228Flammable solid
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 74 °C / 165.2 °F |
| Transport (UN / ADR) | UN 1325 4.1 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Methyltrifluoroacetamide used for?
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N-Methyltrifluoroacetamide is primarily used as a building block and intermediate in organic synthesis, particularly for creating fluorinated organic compounds and in specialty chemical applications.
What is the CAS number and molecular formula for N-Methyltrifluoroacetamide?
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The CAS number for N-Methyltrifluoroacetamide is 815-06-5, and its linear formula is CF3CONHCH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-Methyltrifluoroacetamide with an assay of ≥98.0% (GC), in purum grade. We do not represent this product as USP, BP, or EP grade.
How should N-Methyltrifluoroacetamide be handled safely?
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N-Methyltrifluoroacetamide is a flammable solid and causes skin irritation, serious eye irritation, and respiratory irritation. Handle with appropriate personal protective equipment, including eye shields, gloves, and a dust mask (N95 US type). Ensure good ventilation and keep away from heat and open flames.
How is N-Methyltrifluoroacetamide packed, shipped, and exported?
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N-Methyltrifluoroacetamide is packed, shipped, and exported in compliance with all relevant regulations for hazardous materials, including its classification as a flammable solid (UN 1325, 4.1/PGII).
How can I request a sample or quote for N-Methyltrifluoroacetamide?
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To request a sample or quote for N-Methyltrifluoroacetamide, please contact our sales department through the provided channels on the Tech Serve Solutions website.
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