1-(2-Tetrahydropyranyl)-1H-pyrazole
1-(2-Tetrahydropyranyl)-1H-pyrazole (CAS 449758-17-2; C8H12N2O; molar mass 152.19 g/mol) is a heterocyclic building block in which the pyrazole N-H is protected with a tetrahydropyran-2-yl (THP) group. Supplied as a liquid of around 95% assay, it serves chiefly in organic and medicinal chemistry as a starter for pyrazolylboronic esters and other N-protected pyrazole derivatives. Tech Serve Solutions supplies it as a research/technical-grade product to laboratories and fine-chemical manufacturers worldwide.
- IUPAC
- 1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole
- Synonyms
- 1-(2-Tetrahydropyranyl)-1H-pyrazole1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole1-(Oxan-2-yl)-1H-pyrazole2-(1H-Pyrazol-1-yl)tetrahydro-2H-pyranTHP-protected pyrazole
Precursor to pyrazolylboronic esters
This THP-protected pyrazole is a valued starting material for preparing pyrazolylboronic esters, which act as coupling partners in metal-catalysed cross-coupling chemistry.
Heterocyclic building block
It is used as a C7-C8 building block in chemical synthesis, providing an N-protected pyrazole core for elaboration into more complex heterocyclic structures.
Synthesis of pyrazole derivatives
The compound supports the preparation of pyrazoloisoindoles and other functionalised pyrazole derivatives, where the THP group masks the reactive ring nitrogen during downstream steps.
Protecting-group chemistry
The tetrahydropyran-2-yl group offers acid-labile protection of the pyrazole nitrogen, allowing selective transformations elsewhere on the molecule before deprotection.
Medicinal and discovery chemistry
As a pyrazole-based intermediate, it is suited to research and discovery programmes that build pharmaceutical and agrochemical scaffolds around the pyrazole motif.
| Molecular weight | 152.19 |
|---|---|
| Empirical formula | C8H12N2O |
| Assay | 95% |
| Density | 1.084 g/mL at 25 °C |
| Refractive index | n20/D 1.503 |
| Application | 1-THP-protected 1H-pyrazole as the valuable starter for the preparation of pyrazolylboronic ester, which is useful in the synthesis of pyrazoloisoindoles and other pyrazole derivatives1,2 |
| Flash point | 104 °C / 219.2 °F |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(2-Tetrahydropyranyl)-1H-pyrazole used for?
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It is used mainly as a synthetic building block. The THP-protected pyrazole is a starter for pyrazolylboronic esters and for the preparation of pyrazoloisoindoles and other pyrazole derivatives, where the tetrahydropyranyl group protects the ring nitrogen during synthesis.
What is the CAS number and molecular formula of 1-(2-Tetrahydropyranyl)-1H-pyrazole?
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Its CAS number is 449758-17-2 and its molecular formula is C8H12N2O, with a molecular weight of 152.19 g/mol. The MDL number is MFCD11044692 and it is also known as 1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this material at a typical assay of around 95% as a research/technical-grade building block. It is offered for synthetic and laboratory use; we do not represent it as USP, BP or EP pharmacopoeia grade. A certificate of analysis is provided with each batch.
How should 1-(2-Tetrahydropyranyl)-1H-pyrazole be handled and stored?
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Handle it as a combustible organic liquid with a flash point of about 104 °C; keep away from heat, sparks and open flame, and use suitable ventilation, gloves and eye protection. It is classified WGK 3 (highly hazardous to water in Germany), so prevent any release to drains or watercourses. Store tightly closed in a cool, dry, well-ventilated place and consult the current SDS before use.
How is 1-(2-Tetrahydropyranyl)-1H-pyrazole packed, shipped and exported?
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It is packed in appropriately sealed containers sized to your order, from gram quantities to bulk, with full labelling and documentation. Tech Serve Solutions exports worldwide in line with applicable dangerous-goods and country-specific transport regulations, supplying SDS and certificate of analysis with each consignment.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and destination, and our team will respond with availability, lead time and a formal quotation. Samples can be arranged for evaluation, subject to availability and regulatory requirements.
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