1-(2-Pyrimidyl)piperazine
1-(2-Pyrimidyl)piperazine (CAS 20980-22-7; C8H12N4; molar mass 164.21 g/mol), also known as 2-(1-piperazinyl)pyrimidine, is a heterocyclic building block pairing a piperazine ring with a pyrimidine substituent. Supplied by Tech Serve Solutions at 98% assay, it is a versatile bifunctional intermediate widely used in pharmaceutical and fine-chemical synthesis, where the secondary amine offers a convenient handle for alkylation, acylation and coupling reactions in medicinal-chemistry research.
- IUPAC
- 2-(1-Piperazinyl)pyrimidine
- Synonyms
- 1-(2-Pyrimidyl)piperazine2-(1-Piperazinyl)pyrimidine2-(Piperazin-1-yl)pyrimidine1-(2-Pyrimidinyl)piperazine1-Pyrimidin-2-ylpiperazine
Pharmaceutical intermediate
Used as a building block in the synthesis of pharmaceutical compounds, where the free piperazine nitrogen is readily functionalised. It is a structural fragment associated with the azapirone class of anxiolytics, including buspirone.
Medicinal-chemistry building block
The bifunctional pyrimidinyl-piperazine scaffold is a popular motif in drug-discovery and structure-activity studies. Its secondary amine supports alkylation, acylation, reductive amination and N-arylation to generate diverse analogues.
Heterocyclic synthesis
Serves as a reagent for constructing nitrogen-rich heterocyclic systems. The combination of piperazine and pyrimidine rings makes it useful for assembling more complex polycyclic frameworks.
Laboratory research and development
Employed as a reference and synthetic intermediate in research and process-development laboratories. The 98% assay grade is suited to exploratory chemistry and method development.
| Molecular weight | 164.21 |
|---|---|
| Empirical formula | C8H12N4 |
| Assay | 98% |
| Boiling point | 277 °C(lit.) |
| Density | 1.158 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.587(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | >110 °C / >230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(2-Pyrimidyl)piperazine used for?
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It is used mainly as a fine-chemical and pharmaceutical building block. The pyrimidinyl-piperazine scaffold appears in medicinal-chemistry research and is a structural fragment of the azapirone anxiolytics such as buspirone, and the reactive secondary amine makes it valuable for synthesising analogues and other nitrogen heterocycles.
What is the CAS number and molecular formula of 1-(2-Pyrimidyl)piperazine?
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The CAS number is 20980-22-7 and the molecular formula is C8H12N4, with a molecular weight of 164.21 g/mol. It is also identified by EC number 244-135-5 and MDL number MFCD00040742, and is also known as 2-(1-piperazinyl)pyrimidine.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-(2-Pyrimidyl)piperazine at a typical assay of 98%, as a technical/research-grade reagent intended for synthesis and laboratory use. We do not represent this material as USP, BP or EP pharmacopoeial grade. A certificate of analysis can be provided with each batch on request.
What are the safety and handling precautions for 1-(2-Pyrimidyl)piperazine?
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It is classified under GHS07 with the signal word Warning. It causes skin irritation (H315), serious eye irritation (H319) and may cause respiratory irritation (H335). Handle with gloves and eye protection, avoid breathing dust or vapour, and ensure adequate ventilation (P261, P305+P351+P338). It is assigned WGK 3 (highly hazardous to water), so prevent release to the environment. Always consult the Safety Data Sheet before use.
How is 1-(2-Pyrimidyl)piperazine packed, shipped and exported?
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It is supplied in securely sealed containers sized to the order, with tamper-evident packaging and full batch labelling. Tech Serve Solutions exports worldwide with complete documentation, including the Safety Data Sheet and certificate of analysis. Packaging and transport are arranged in line with applicable dangerous-goods and destination-country requirements.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and destination, and we will respond with availability, lead time and a formal quotation. Samples can be arranged for evaluation, subject to availability and regulatory requirements.
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