1-(2-Pyridylcarbonyl)benzotriazole
1-(2-Pyridylcarbonyl)benzotriazole (CAS 144223-29-0) is a benzotriazole-activated acylating reagent with the molecular formula C12H8N4O and a molar mass of 224.22 g/mol. Supplied as a crystalline solid (melting point 117–124 °C), it transfers a 2-pyridoyl group under mild conditions and serves chiefly in chemical synthesis: acylation of organometallic reagents, preparation of acyl azides and pyridylcarboxylato metal complexes. Tech Serve Solutions supplies it as a research-grade reagent at 97% assay.
- Synonyms
- 1-(2-Pyridylcarbonyl)benzotriazole1-(1H-benzotriazol-1-yl)(pyridin-2-yl)methanone(1H-benzo[d][1,2,3]triazol-1-yl)(pyridin-2-yl)methanone2-(1H-benzotriazol-1-ylcarbonyl)pyridine1-(2-pyridoyl)benzotriazolepyridin-2-yl 1H-benzotriazol-1-yl ketone
Acylation of organometallic reagents
Acts as a stable 2-pyridoyl transfer reagent for the acylation of Grignard and heteroaryllithium reagents, providing access to 2-pyridyl ketones under controlled conditions.
Preparation of acyl azides
Reacts with sodium azide to furnish the corresponding acyl azide, a useful intermediate for downstream Curtius-type chemistry and further functionalisation.
Synthesis of pyridylcarboxylato metal complexes
Used as a reactant in the preparation of ruthenium(II) benzotriazole triphenylphosphine pyridylcarboxylato chloro complexes for coordination and organometallic studies.
Chemoselective reduction substrate
Serves as a reactant in chemoselective reduction reactions, where the benzotriazolide activation enables selective transformations of the carbonyl centre.
C–C bond formation and research synthesis
A benzotriazole-mediated synthetic reagent for C–C bond formation, supporting laboratory-scale method development across pharmaceutical-intermediate and fine-chemical research.
| Molecular weight | 224.22 |
|---|---|
| Empirical formula | C12H8N4O |
| Assay | 97% |
| Application | Reactant for:• Preparation of ruthenium(II) benzotriazole triphenylphosphine pyridylcarboxylato chloro complex1• Preparation of acyl azides via reactions with sodium azide2• Acylation of Grignard and heteroaryllithium reagents3• Chemoselective reduction reactions4 |
| Melting point | 117-124 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
| Safety statements (S) | 36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(2-Pyridylcarbonyl)benzotriazole used for?
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It is a benzotriazole-activated acylating reagent used in chemical synthesis. Principal uses include the acylation of Grignard and heteroaryllithium reagents, preparation of acyl azides from sodium azide, synthesis of pyridylcarboxylato metal complexes and chemoselective reduction reactions. It is intended for research and laboratory applications.
What is the CAS number and molecular formula of 1-(2-Pyridylcarbonyl)benzotriazole?
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The CAS number is 144223-29-0 and the molecular formula is C12H8N4O (Hill notation), with a molecular weight of 224.22 g/mol. The MDL number is MFCD00962969. It is a crystalline solid with a melting point of 117–124 °C.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-(2-Pyridylcarbonyl)benzotriazole as a research-grade synthetic reagent with a typical assay of 97%. We do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis can be provided with each batch on request.
What are the safety and handling requirements for this reagent?
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It is classified GHS07 with the signal word Warning and hazard statement H302 (harmful if swallowed). Avoid ingestion, handle with eye protection and gloves, and use a type N95 dust mask to limit inhalation. It carries a German Water Hazard Class (WGK) of 3, so prevent release to drains and water. Always consult the Safety Data Sheet before use.
How is 1-(2-Pyridylcarbonyl)benzotriazole packed, shipped and exported?
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It is packed as a solid in tightly sealed containers sized from gram research quantities to larger laboratory packs, with labelling and documentation appropriate to the order. As a global supplier and exporter, Tech Serve Solutions arranges export shipments with the required SDS and certificate of analysis. Contact us for available pack sizes and lead times.
How do I request a sample or quote?
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Send your required quantity, pack size and destination to Tech Serve Solutions and our team will respond with availability, lead time and a formal quotation. Samples may be available for qualification; please specify your application when enquiring.
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