1-(2-Pyrimidyl)piperazine dihydrochloride
1-(2-Pyrimidyl)piperazine dihydrochloride (CAS 94021-22-4) is the dihydrochloride salt of 1-(2-pyrimidyl)piperazine, with molecular formula C8H12N4 · 2HCl and a molar mass of 237.13 g/mol. It is a crystalline heterocyclic building block that pairs a pyrimidine ring with a piperazine, supplied at 98% assay. The salt form improves stability and handling, and it is used principally in research and pharmaceutical-intermediate synthesis as a versatile arylpiperazine fragment.
- IUPAC
- 2-(1-Piperazinyl)pyrimidine dihydrochloride,2-Piperazinopyrimidine dihydrochloride
- Synonyms
- 1-(2-Pyrimidyl)piperazine dihydrochloride2-(1-Piperazinyl)pyrimidine dihydrochloride2-Piperazinopyrimidine dihydrochloride1-(2-Pyrimidinyl)piperazine dihydrochloride2-(Piperazin-1-yl)pyrimidine dihydrochloride
Pharmaceutical intermediate
Serves as a 2-substituted arylpiperazine building block in the synthesis of active pharmaceutical ingredients and drug candidates. The 2-pyrimidinylpiperazine motif is a recurring fragment in medicinal chemistry programmes.
Heterocyclic building block
Used in chemical synthesis to introduce a combined pyrimidine and piperazine scaffold in a single step. The free secondary amine on the piperazine ring offers a convenient site for alkylation, acylation and reductive amination.
Medicinal chemistry and discovery research
Applied in library design and structure-activity studies where an arylpiperazine pharmacophore is required. It is a well-characterised reference fragment for exploratory and lead-optimisation work.
Reference and analytical use
The defined dihydrochloride salt provides a consistent, well-documented standard for method development, identity confirmation and analytical reference work in laboratory settings.
| Molecular weight | 237.13 |
|---|---|
| Empirical formula | C8H12N4 · 2HCl |
| Assay | 98% |
| Melting point | 282-287 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(2-Pyrimidyl)piperazine dihydrochloride used for?
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It is used chiefly as a heterocyclic building block and pharmaceutical intermediate in chemical synthesis. The 2-pyrimidinylpiperazine fragment is a common arylpiperazine motif in medicinal chemistry, and the free piperazine nitrogen is readily functionalised by alkylation, acylation or reductive amination.
What is the CAS number and molecular formula of 1-(2-Pyrimidyl)piperazine dihydrochloride?
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Its CAS number is 94021-22-4 and its molecular formula is C8H12N4 · 2HCl, corresponding to a molecular weight of 237.13 g/mol. Related identifiers include EC 301-415-2, MDL MFCD00012779 and Beilstein 151178.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-(2-Pyrimidyl)piperazine dihydrochloride at a typical assay of 98% as a research and technical grade material. We do not represent it as USP, BP or EP pharmacopoeia grade. A certificate of analysis accompanies each batch, and specifications can be confirmed on enquiry.
What are the safety and handling precautions for this compound?
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It is classified GHS07 with the signal word Warning and carries hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves, eye protection and an N95-type dust mask, avoid dust formation, and consult the Safety Data Sheet before use. It is rated WGK 3 (highly hazardous to water in Germany), so prevent release to the environment.
How is 1-(2-Pyrimidyl)piperazine dihydrochloride packed, shipped and exported?
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The material is packed in sealed, labelled containers appropriate to the order size, from gram quantities to bulk, with packaging suited to a moisture-sensitive crystalline salt. Each consignment ships with a certificate of analysis and Safety Data Sheet, and we handle export documentation and global logistics in line with the applicable transport regulations.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and destination, and our team will respond with availability, lead time and a formal quotation. Samples can be arranged for qualification subject to availability.
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