1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid neopentylglycol ester
1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid neopentylglycol ester (CAS 1072944-26-3; molecular formula C13H21BN2O3; molecular weight 264.13) is a heteroaryl boronate ester reagent supplied as a solid melting at 88-93 C. It pairs a THP-protected pyrazole with a neopentylglycol boronate, giving a bench-stable coupling partner. It is used principally as a building block in Suzuki-Miyaura cross-coupling for pharmaceutical and agrochemical synthesis.
- IUPAC
- 1-(Tetrahydro-2H-pyran-2-yl)-4-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)-pyrazole,1-(THP)-4-(Neopentylglycolato)-pyrazole
- Synonyms
- 1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid neopentylglycol ester1-(Tetrahydro-2H-pyran-2-yl)-4-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)-pyrazole1-(THP)-4-(Neopentylglycolato)-pyrazole4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazoleCAS 1072944-26-3
Suzuki-Miyaura cross-coupling partner
The neopentylglycol boronate serves as the organoboron component in palladium-catalysed Suzuki-Miyaura reactions, forming carbon-carbon bonds with aryl and heteroaryl halides. It introduces a substituted pyrazole ring onto a target scaffold.
Pharmaceutical intermediate
As a protected pyrazole boronate, it is employed in medicinal-chemistry routes to construct pyrazole-containing drug candidates and intermediates. The THP group masks the pyrazole N-H during downstream chemistry.
Agrochemical building block
Pyrazole motifs are common in crop-protection actives, and this reagent provides a convenient route to install them via cross-coupling. It supports discovery and process chemistry in the agrochemical sector.
Heterocyclic library synthesis
The reagent is useful for parallel and diversity-oriented synthesis, enabling rapid assembly of pyrazole-substituted analogues for screening libraries.
Protected boronate handle
The neopentylglycol ester offers improved handling and stability relative to the free boronic acid, while the THP protecting group can be removed later to reveal the free pyrazole N-H.
| Molecular weight | 264.13 |
|---|---|
| Empirical formula | C13H21BN2O3 |
| Assay | 95% |
| Melting point | 88-93 °C |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid neopentylglycol ester used for?
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It is used chiefly as an organoboron building block in Suzuki-Miyaura cross-coupling, introducing a THP-protected pyrazole ring into pharmaceutical and agrochemical intermediates. The neopentylglycol boronate acts as the transmetalation partner with aryl or heteroaryl halides under palladium catalysis.
What is the CAS number and molecular formula of 1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid neopentylglycol ester?
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The CAS number is 1072944-26-3. The molecular formula is C13H21BN2O3, with a molecular weight of 264.13 g/mol. It is a solid with a melting point of 88-93 C.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this reagent at a typical assay of 95%, as a research and synthesis grade material. We do not represent it as a USP, BP or EP pharmacopoeial grade. A specification or certificate of analysis can be provided with each batch on request.
What are the safety and handling considerations?
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A full GHS classification is not established in the supplied data, so handle it as a laboratory chemical of unknown hazard: use gloves, eye protection and adequate ventilation, and avoid dust, skin and eye contact. It carries German Water Hazard Class WGK 3 (severely hazardous to water), so keep it out of drains and waterways. Always consult the current Safety Data Sheet before use.
How is 1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid neopentylglycol ester packed, shipped and exported?
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It is packed as a solid in tightly closed containers sized from gram research quantities to larger bulk orders, with appropriate inner protection. Tech Serve Solutions exports worldwide with full documentation, including the Safety Data Sheet and certificate of analysis, and arranges compliant labelling and transport.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity and destination to receive a quotation, lead time and available specification. Samples can be arranged on request, subject to availability.
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