1-(2-Thienylcarbonyl)-1H-benzotriazole
1-(2-Thienylcarbonyl)-1H-benzotriazole (CAS 301164-69-2; C11H7N3OS; molar mass 229.26 g/mol) is a crystalline N-acylbenzotriazole reagent that carries a thiophene-2-carbonyl group on the benzotriazole nitrogen. As a stable, easily handled acyl-transfer reagent, it delivers the 2-thienylcarbonyl (thiophene-2-carbonyl) unit to amines, alcohols and carbon nucleophiles, supporting amide, ester and ketone formation. Tech Serve Solutions supplies it as a research-grade synthetic intermediate to laboratories worldwide.
- Synonyms
- 1-(2-Thienylcarbonyl)-1H-benzotriazole1-(Thiophene-2-carbonyl)-1H-benzotriazole1-(1H-Benzotriazol-1-yl)(thiophen-2-yl)methanone(1H-Benzo[d][1,2,3]triazol-1-yl)(thiophen-2-yl)methanone2-Thienyl benzotriazol-1-yl ketoneN-(2-Thenoyl)benzotriazole
Acyl-transfer reagent
Acts as a benzotriazole-activated equivalent of thiophene-2-carbonyl chloride, transferring the 2-thienylcarbonyl group to nucleophiles under mild conditions. The benzotriazole leaving group makes it a convenient, bench-stable alternative to the corresponding acid chloride.
Amide and peptide-type coupling
N-Acylbenzotriazoles react with primary and secondary amines to give the corresponding amides, often without an added coupling agent. This makes the reagent useful for introducing a thiophene-2-carboxamide motif in medicinal and exploratory synthesis.
Ester and O-acylation
The reagent acylates alcohols and phenols to furnish thiophene-2-carboxylate esters. It offers a controlled route to O-acylated products where a stable, isolable acylating agent is preferred over an acid chloride or anhydride.
C-acylation and C-C bond formation
In line with its C-C bond formation classification, the reagent can acylate suitable carbon nucleophiles, providing access to thienyl ketones and related building blocks for heterocyclic chemistry.
Research and discovery building block
Used as a thiophene-bearing synthetic intermediate in pharmaceutical and agrochemical discovery research, where the thiophene-2-carbonyl group is a recurring structural feature.
| Molecular weight | 229.26 |
|---|---|
| Empirical formula | C11H7N3OS |
| Assay | 97% |
| Melting point | 175-179 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
| Safety statements (S) | 36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(2-Thienylcarbonyl)-1H-benzotriazole used for?
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It is used as a stable N-acylbenzotriazole acyl-transfer reagent that delivers the thiophene-2-carbonyl group to amines, alcohols and carbon nucleophiles. This supports the preparation of thiophene-2-carboxamides, esters and ketones, offering a convenient, bench-stable alternative to thiophene-2-carbonyl chloride in chemical synthesis.
What is the CAS number and molecular formula of 1-(2-Thienylcarbonyl)-1H-benzotriazole?
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The CAS number is 301164-69-2 and the molecular formula is C11H7N3OS, with a molecular weight of 229.26 g/mol. The MDL number is MFCD00583990. It is a crystalline solid with a reported melting point of 175-179 °C.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-(2-Thienylcarbonyl)-1H-benzotriazole at a typical assay of 97% as a research and laboratory-reagent grade material. We do not represent it as a USP, BP or EP pharmacopoeial grade. A certificate of analysis can be provided on request, and exact specifications are confirmed at the time of enquiry.
What are the safety and handling requirements for this reagent?
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It is classified under GHS07 with the signal word Warning and the hazard statement H302 (harmful if swallowed). Handle it in a well-ventilated area, avoid ingestion and dust formation, and use suitable personal protective equipment including an N95-type dust mask, eye protection and gloves. It carries Water Hazard Class WGK 3 in Germany, so prevent release to drains and watercourses. Always consult the Safety Data Sheet before use.
How is 1-(2-Thienylcarbonyl)-1H-benzotriazole packed, shipped and exported?
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It is supplied as a solid in securely sealed laboratory and bulk containers, labelled in accordance with GHS requirements and accompanied by the relevant documentation. Tech Serve Solutions exports worldwide and arranges packaging and shipping appropriate to the order size and destination regulations.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and destination, and our team will respond with availability, documentation and a quotation. Sample availability can be confirmed at the time of enquiry.
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