(+)-1,2-Bis[(2R,5R)-2,5-dimethylphospholano]ethane
(+)-1,2-Bis[(2R,5R)-2,5-dimethylphospholano]ethane (CAS: 129648-07-3) is a chiral diphosphine ligand with the molecular formula C14H28P2 and a molecular weight of 258.32 g/mol. It belongs to the BPE class of ligands, known for their high efficacy in asymmetric catalysis. This compound is primarily utilised in asymmetric synthesis for creating chiral molecules, serving as a crucial component in various catalytic processes.
- IUPAC
- (R,R)-Me-BPE
- Synonyms
- (+)-1,2-Bis[(2R,5R)-2,5-dimethylphospholano]ethane(R,R)-Me-BPE5R)-2C14H28P2
![(+)-1,2-Bis[(2R,5R)-2,5-dimethylphospholano]ethane (5R)-2) — chemical structure, CAS 129648-07-3; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F129648-07-3.png&w=3840&q=75)
Asymmetric Catalysis
This chiral diphosphine ligand is extensively used in metal-catalyzed asymmetric reactions, enabling the enantioselective synthesis of valuable chiral compounds. Its structure facilitates high stereocontrol in hydrogenation, cyclopropanation, and other transformations.
Chiral Ligand in Synthesis
As a privileged ligand, it plays a vital role in the development of new synthetic methodologies. It can be coordinated with various transition metals to form highly active and selective catalysts for complex molecule synthesis.
DuPhos and BPE Ligands
This compound is a key example within the DuPhos and BPE ligand families, recognised for their broad applicability and exceptional performance in stereoselective catalysis across the pharmaceutical and fine chemical industries.
| Molecular weight | 258.32 |
|---|---|
| Empirical formula | C14H28P2 |
| Boiling point | 64-67 °C/0.06 mmHg |
| Density | 0.940 g/mL at 25 °C |
| Refractive index | n20/D 1.534 |
| Application | DuPhos and BPE Ligands: Highly Efficient Privileged Ligands |
Hazard statements
- H250Catches fire spontaneously if exposed to air
- H413May cause long-lasting harmful effects to aquatic life
Precautionary statements
- P222Do not allow contact with air
- P231Handle under inert gas
- P422
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 2845 4.2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F |
| Risk statements (R) | 11-17 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (+)-1,2-Bis[(2R,5R)-2,5-dimethylphospholano]ethane used for?
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This compound is primarily used as a chiral diphosphine ligand in asymmetric synthesis and catalysis, facilitating enantioselective transformations.
What is the CAS number and molecular formula?
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The CAS number is 129648-07-3, and the molecular formula is C14H28P2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical for research and laboratory use. The specific purity and grade are detailed in the product specifications. We do not represent this product as USP, BP, EP, or for any pharmacopoeia, nutraceutical, or food applications unless explicitly stated in the product specifications.
How should (+)-1,2-Bis[(2R,5R)-2,5-dimethylphospholano]ethane be handled safely?
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This compound is a pyrophoric solid (H250) that may ignite spontaneously in air and is harmful to aquatic life with long-lasting effects (H413). Handle under an inert atmosphere (P231, P422) and wear appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator (refer to safety data sheet for details).
Is this chemical suitable for export?
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Yes, Tech Serve Solutions is an experienced global supplier and exporter of fine chemicals, including this compound, adhering to all relevant shipping regulations.
How can I request a sample or quote?
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Please contact our sales department through the website or by phone to request a sample or a quotation for (+)-1,2-Bis[(2R,5R)-2,5-dimethylphospholano]ethane.
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