(+)-1,2-Bis[(2R,5R)-2,5-diisopropylphospholano]benzene

CAS 136705-65-25R)-2Chemical Synthesis

(+)-1,2-Bis[(2R,5R)-2,5-diisopropylphospholano]benzene (CAS: 136705-65-2), with the molecular formula C26H44P2 and a molecular weight of 418.58 g/mol, is a crucial chiral ligand. It is widely recognised for its application in asymmetric synthesis, facilitating enantioselective catalytic transformations. This compound is a key component in advanced chemical synthesis and a vital reagent in the field of chiral catalysis, enabling the production of stereochemically pure compounds.

IUPAC: (R,R)-i-Pr-DUPHOS
Synonyms: (+)-1,2-Bis[(2R,5R)-2,5-diisopropylphospholano]benzene(R,R)-i-Pr-DUPHOS

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(+)-1,2-Bis[(2R,5R)-2,5-diisopropylphospholano]benzene (5R)-2) — chemical structure, CAS 136705-65-2; Chemistry, fine chemical supplied by Tech Serve Solutions

Asymmetric SynthesisChemical SynthesisChiral CatalystsLigandsand ReagentsDuPhos/BPE

01 /Applications

Asymmetric Catalysis

This phosphine ligand is extensively employed in asymmetric catalysis to achieve high enantioselectivity in various chemical reactions. Its structure enables precise control over the stereochemical outcome of transformations, making it invaluable for the synthesis of chiral molecules.

Chiral Ligand in Synthesis

As a privileged chiral ligand, it plays a significant role in facilitating enantioselective hydrogenations, isomerisations, and other catalytic processes. Its application is critical in producing enantiomerically pure pharmaceutical intermediates and fine chemicals.

DuPhos/BPE Ligand Class

Belonging to the highly efficient DuPhos and BPE ligand family, this compound offers exceptional catalytic performance. These ligands are known for their robustness and broad applicability in metal-catalysed asymmetric reactions.

02 /Properties

Molecular weight	418.58
Empirical formula	C26H44P2
Refractive index	n20/D 1.5701
Optical activity	[α]20/D +103°, c = 1 in chloroform
Application	DuPhos and BPE Ligands: Highly Efficient Privileged Ligands

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Flash point	>110 °C / >230 °F
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

136705-65-2

MDL number

MFCD02684549

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is (+)-1,2-Bis[(2R,5R)-2,5-diisopropylphospholano]benzene used for?

(+)-1,2-Bis[(2R,5R)-2,5-diisopropylphospholano]benzene is primarily used as a chiral ligand in asymmetric synthesis and catalysis, enabling the enantioselective production of various chemical compounds.

What are the CAS number and formula for this compound?

The CAS number is 136705-65-2, and the empirical formula is C26H44P2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this compound for research and chemical synthesis purposes. The specific grade and purity are available upon request or detailed in the product's Certificate of Analysis. We do not represent this product as meeting USP, BP, or EP pharmacopoeial standards.

How should (+)-1,2-Bis[(2R,5R)-2,5-diisopropylphospholano]benzene be handled?

Handling requires appropriate personal protective equipment, including eyeshields and gloves. Ensure adequate ventilation, and use a type N95 (US) or P1 (EN143) respirator if airborne exposure is possible. It has a flash point above 110 °C.