(+)-1,2-Bis[(2S,5S)-2,5-dimethylphospholano]benzene

CAS 136735-95-05S)-2Chemical Synthesis

(+)-1,2-Bis[(2S,5S)-2,5-dimethylphospholano]benzene (CAS: 136735-95-0) is a chiral diphosphine ligand with the molecular formula C18H28P2 and a molecular weight of 306.36 g/mol. It belongs to the privileged class of DuPhos ligands, widely recognised for their exceptional efficacy in catalysing asymmetric transformations. This compound is a key reagent in asymmetric synthesis, facilitating the production of enantiomerically pure compounds.

IUPAC: (2S,2′S,5S,5′S)-2,2′,5,5′-Tetramethyl-1,1′-(o-phenylene)diphospholane,(S,S)-Me-DUPHOS,(S,S)-Methyl-DUPHOS
Synonyms: (S,S)-Me-DUPHOS(S,S)-Methyl-DUPHOS(2S,2′S,5S,5′S)-2,2′,5,5′-Tetramethyl-1,1′-(o-phenylene)diphospholane

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(+)-1,2-Bis[(2S,5S)-2,5-dimethylphospholano]benzene (5S)-2) — chemical structure, CAS 136735-95-0; Chemistry, fine chemical supplied by Tech Serve Solutions

Asymmetric SynthesisChemical SynthesisChiral CatalystsLigandsand ReagentsDuPhos/BPE

01 /Applications

Asymmetric Catalysis

This chiral diphosphine ligand is extensively employed in transition metal catalysis for asymmetric hydrogenation, hydroformylation, and other enantioselective reactions. It enables the synthesis of chiral molecules with high enantioselectivity.

Chiral Ligand in Synthesis

As a highly efficient privileged ligand, it plays a crucial role in developing novel synthetic methodologies for producing enantiomerically enriched pharmaceuticals and fine chemicals. Its unique structure facilitates superior catalytic performance.

Chemical Synthesis

Utilised as a key component in sophisticated chemical syntheses, this compound contributes to the development of complex molecular architectures requiring precise stereochemical control. It is valuable in both academic research and industrial applications.

02 /Properties

Molecular weight	306.36
Empirical formula	C18H28P2
Application	DuPhos and BPE Ligands: Highly Efficient Privileged Ligands
Melting point	67-76 °C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

136735-95-0

MDL number

MFCD00142322

PubChem substance

24884725

Beilstein registry

4810602

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is (+)-1,2-Bis[(2S,5S)-2,5-dimethylphospholano]benzene used for?

(+)-1,2-Bis[(2S,5S)-2,5-dimethylphospholano]benzene is primarily used as a chiral diphosphine ligand in asymmetric catalysis for reactions such as asymmetric hydrogenation and hydroformylation.

What is the CAS number and molecular formula?

The CAS number is 136735-95-0, and the molecular formula is C18H28P2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this compound for research and chemical synthesis. Purity and specific grades are detailed in the product specifications. We do not represent this product as USP, BP, or EP grade.

How should (+)-1,2-Bis[(2S,5S)-2,5-dimethylphospholano]benzene be handled safely?

This compound requires careful handling. Use in a well-ventilated area with appropriate personal protective equipment, including eyeshields and gloves. Respiratory protection with a type N95 (US) or type P1 (EN143) filter is recommended. It is classified with a WGK Germany of 3, indicating a high hazard to water.

How is this chemical shipped?

Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents, adhering to all necessary regulations for safe and compliant international shipping.

How can I request a sample or quote?

To request a sample or quote for (+)-1,2-Bis[(2S,5S)-2,5-dimethylphospholano]benzene, please contact our sales department through the website or by phone.