(S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride
(S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride (CAS 20445-33-4) is a chiral acid halide with the formula C₆H₅C(OCH₃)(CF₃)COCl and a molecular weight of 252.62 g/mol. This compound serves as a valuable reagent in asymmetric synthesis, particularly for the preparation of natural products and pheromones. Its unique chiral structure makes it instrumental in creating stereochemically defined molecules in organic synthesis.
- IUPAC
- (S)-(+)-MTPA-Cl,Mosher’s acid chloride
- Synonyms
- (S)-(+)-MTPA-Cl, Mosher’s acid chloride
Chiral Derivatizing Agent
This compound is frequently employed as a chiral derivatizing agent to determine the enantiomeric purity of alcohols and amines through the formation of diastereomeric esters or amides.
Synthesis of Natural Products
It is utilized in the synthetic routes for various complex natural products, where its chiral nature is essential for establishing specific stereocenters within the target molecule.
Pheromone Synthesis
The compound finds application in the preparation of insect pheromones, which often require precise stereochemistry for biological activity.
Asymmetric Synthesis
As a chiral building block, it facilitates the construction of enantiomerically enriched compounds, critical for pharmaceutical and agrochemical research and development.
| Molecular weight | 252.62 |
|---|---|
| Linear formula | C6H5C(OCH3)(CF3)COCl |
| Assay | 99% |
| Boiling point | 213-214 °C(lit.) |
| Density | 1.35 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.469(lit.) |
| Optical purity | ee: 98% (GLC) |
| Storage temperature | −20°C |
| Application | Used in the synthesis of natural products1,2 and pheromones.3 |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 89 °C / 192.2 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride used for?
+
(S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride (CAS 20445-33-4) is primarily used as a chiral derivatizing agent for determining enantiomeric purity and as a chiral building block in the synthesis of natural products and pheromones.
What are the CAS number and chemical formula for this product?
+
The CAS number is 20445-33-4, and the linear chemical formula is C₆H₅C(OCH₃)(CF₃)COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of 99% and an optical purity of ee: 98% (GLC). We do not represent this product as USP, BP, or EP grade.
How should (S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride be handled safely?
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This compound is corrosive and can cause severe skin burns and eye damage (H314). Handle with appropriate personal protective equipment including full-face respirators, chemical-resistant gloves, and goggles. Ensure adequate ventilation. Store under a dry atmosphere at -20°C.
Is this product shipped or exported internationally by TSS?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including (S)-(+)-α-Methoxy-α-trifluoromethylphenylacetyl chloride.
How can I request a quote or sample?
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To request a quote or sample, please contact our sales team through the website or by phone, providing the product name and CAS number (20445-33-4).
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