4-(Trifluoromethyl)phenol
4-(Trifluoromethyl)phenol (CAS: 402-45-9), with the chemical formula CF3C6H4OH and a molecular weight of 162.11 g/mol, is a fluorinated organic compound. It serves as a valuable building block in chemical synthesis, particularly in the preparation of more complex molecules. This phenol derivative is recognised for its utility in constructing specific molecular architectures within research and development settings.
- IUPAC
- α,α,α-Trifluoro-p-cresol,4-Hydroxybenzotrifluoride
- Synonyms
- α,α,α-Trifluoro-p-cresol4-Hydroxybenzotrifluoride
Synthesis of Diaryl Ethers
4-(Trifluoromethyl)phenol has been employed as a reactant in the synthesis of diaryl ether compounds. This application leverages the reactivity of the phenolic hydroxyl group and the electronic influence of the trifluoromethyl substituent.
Organic Building Block
As a versatile organic building block, this compound is utilised in various synthetic pathways. Its structure allows for diverse chemical transformations, making it a useful intermediate for creating novel compounds in pharmaceutical and material science research.
Fluorinated Intermediate
The presence of the trifluoromethyl group makes 4-(Trifluoromethyl)phenol a key intermediate for introducing fluorine into organic molecules. Fluorinated compounds often exhibit unique properties, driving their use in advanced chemical applications.
| Molecular weight | 162.11 |
|---|---|
| Linear formula | CF3C6H4OH |
| Assay | 97% |
| Storage temperature | 2-8°C |
| Application | 4-(Trifluoromethyl)phenol (4-hydroxybenzotrifluoride) was used in the synthesis of diaryl ether1. |
| Melting point | 45-47 °C(lit.) |
Hazard statements
- H228Flammable solid
- H301Toxic if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Flash point | 84 °C / 183.2 °F |
| Transport (UN / ADR) | UN 2926 4.1/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-37/38-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Trifluoromethyl)phenol used for?
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4-(Trifluoromethyl)phenol is primarily used as a building block in organic synthesis, including the preparation of diaryl ethers and other fluorinated organic compounds.
What is the CAS number and chemical formula for 4-(Trifluoromethyl)phenol?
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The CAS number is 402-45-9 and the chemical formula is CF3C6H4OH.
What grade and purity does Tech Serve Solutions supply for 4-(Trifluoromethyl)phenol?
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Tech Serve Solutions supplies 4-(Trifluoromethyl)phenol with an assay of 97%. This product is intended for laboratory and research use and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
What are the primary safety hazards associated with 4-(Trifluoromethyl)phenol?
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4-(Trifluoromethyl)phenol is a dangerous substance. Hazards include flammable solid (H228), toxic if swallowed (H301), causes skin irritation (H315), causes serious eye damage (H318), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, face shields, and gloves, must be used.
How is 4-(Trifluoromethyl)phenol packed and shipped?
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4-(Trifluoromethyl)phenol is packed and shipped according to UN 2926, Hazard Class 4.1, Packing Group II regulations. TSS is a specialist global supplier and exporter of fine chemicals.
How can I request a quote or sample of 4-(Trifluoromethyl)phenol?
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To request a quote or sample of 4-(Trifluoromethyl)phenol, please contact the Tech Serve Solutions sales team through our website or by telephone.
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