(S)-1-[(RP)-2-(Diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine
(S)-1-[(RP)-2-(Diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine (CAS: 277306-29-3, C32H40FeP2, MW: 542.45) is a chiral phosphine ligand vital for asymmetric synthesis. As a member of the Josiphos family, it excels in catalysing enantioselective transformations. This high-purity ligand is crucial in the development of pharmaceuticals and fine chemicals where precise stereochemical control is paramount, enabling efficient production of enantiomerically enriched compounds.
- IUPAC
- (2S)-1-[(1S)-1-[Bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene (acc to CAS),Josiphos SL-J002-2
![(S)-1-[(RP)-2-(Diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine (C32H40FeP2) — chemical structure, CAS 277306-29-3; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F277306-29-3.png&w=3840&q=75)
Asymmetric Catalysis
This chiral ferrocenyl phosphine ligand is widely employed in transition metal catalysis to promote enantioselective reactions. It is particularly effective in asymmetric hydrogenation and cross-coupling reactions, facilitating the synthesis of chiral molecules with high enantiomeric excess.
Pharmaceutical Intermediate Synthesis
Its ability to control stereochemistry makes it invaluable for the synthesis of complex chiral building blocks and active pharmaceutical ingredients (APIs). This enables the efficient production of single-enantiomer drugs, which often exhibit improved efficacy and reduced side effects.
Fine Chemical Manufacturing
The ligand is used in the production of advanced materials and specialty chemicals requiring specific stereoisomers. Its application ensures the creation of high-value chiral compounds for various industrial sectors.
| Molecular weight | 542.45 |
|---|---|
| Empirical formula | C32H40FeP2 |
| Assay | ≥97% |
| Optical activity | [α]20/D +410±15°, c = 0.5 in chloroform |
| Optical purity | ee: ≥99% |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-1-[(RP)-2-(Diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine used for?
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This compound is primarily used as a chiral ligand in asymmetric catalysis for reactions such as hydrogenation and cross-coupling, enabling the enantioselective synthesis of complex chiral molecules, particularly in the pharmaceutical and fine chemical industries.
What are the CAS number and formula for this chemical?
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The CAS number is 277306-29-3, and the molecular formula is C32H40FeP2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of ≥97% and an optical purity of ee: ≥99%. It is supplied as a research or technical grade material and is not represented as USP, BP, or EP grade.
What are the safety and handling considerations for this product?
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This compound requires careful handling using appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The product has a WGK Germany rating of 3, indicating it is hazardous.
Is this compound a controlled substance?
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Based on the provided data, there is no indication that this compound is a controlled substance.
How can I request a sample or quote for this product?
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To request a sample or quote, please use the contact form on our website or email our sales department directly. Specify the product name and CAS number for prompt service.
How is this chemical packed, shipped, and exported?
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This chemical is carefully packed according to industry standards to ensure safe transport and is exported globally by Tech Serve Solutions. Specific packaging details can be provided upon request for your order.
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