(R)-(−)-Leucinol
(R)-(−)-Leucinol (CAS: 53448-09-2) is a chiral amino alcohol with the linear formula (CH₃)₂CHCH₂CH(NH₂)CH₂OH and a molecular weight of 117.19 g/mol. This compound is a derivative of the amino acid leucine. It is a valuable building block in organic synthesis, particularly for the preparation of chiral ligands, pharmaceuticals, and other complex organic molecules. Its specific stereochemistry makes it essential for stereoselective reactions.
- IUPAC
- (R)-2-Amino-4-methyl-1-pentanol,D-Leucinol
- Synonyms
- (R)-2-Amino-4-methyl-1-pentanolD-Leucinol
Chiral Synthesis
(R)-(−)-Leucinol serves as a chiral auxiliary and building block in asymmetric synthesis. It is employed in the preparation of enantiomerically pure compounds, including pharmaceuticals and fine chemicals, where precise stereochemistry is critical.
Pharmaceutical Intermediates
This amino alcohol is utilised in the synthesis of various pharmaceutical intermediates. Its inherent chirality is leveraged to construct complex drug molecules with specific biological activities.
Ligand Development
It is used in the development of chiral ligands for transition metal catalysis. These ligands are crucial for achieving high enantioselectivity in various catalytic transformations.
Peptide Chemistry
As an amino acid derivative, leucinol finds applications in peptide chemistry, potentially for the synthesis of modified peptides or peptidomimetics with unique properties.
| Molecular weight | 117.19 |
|---|---|
| Linear formula | (CH3)2CHCH2CH(NH2)CH2OH |
| Assay | 98% |
| Boiling point | 198-200 °C/768 mmHg(lit.) |
| Density | 0.917 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.4496(lit.) |
| Optical activity | [α]20/D −4°, c = 9 in ethanol |
| Optical purity | enantiomeric ratio: ≥99:1 (GC) |
| Protective equipment | Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | 90 °C / 194 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(−)-Leucinol used for?
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(R)-(−)-Leucinol is primarily used as a chiral building block in asymmetric synthesis, for the preparation of pharmaceutical intermediates, and in the development of chiral ligands for catalysis.
What is the CAS number and chemical formula for (R)-(−)-Leucinol?
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The CAS number for (R)-(−)-Leucinol is 53448-09-2. Its linear chemical formula is (CH₃)₂CHCH₂CH(NH₂)CH₂OH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-(−)-Leucinol with a minimum assay of 98%. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated in the product documentation.
How is (R)-(−)-Leucinol handled and stored?
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Handle (R)-(−)-Leucinol with appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection as indicated by safety data sheets. Store in a cool, well-ventilated area away from incompatible materials. It has a flash point of 90°C (194°F).
Is (R)-(−)-Leucinol a regulated substance?
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The provided data does not indicate that (R)-(−)-Leucinol is a controlled or scheduled substance. It is classified under NA 1993 / PGIII for transport.
How can I get a quote or sample of (R)-(−)-Leucinol?
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To request a quote or a sample of (R)-(−)-Leucinol, please contact our sales team through the website or by phone, providing the product name and CAS number (53448-09-2).
Is (R)-(−)-Leucinol exported by Tech Serve Solutions?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including (R)-(−)-Leucinol.
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