Semicarbazide hydrochloride
Semicarbazide hydrochloride (CAS: 563-41-7) is an organic compound with the linear formula NH₂CONHNH₂ · HCl and a molecular weight of 111.53 g/mol. This white to off-white crystalline solid serves as a valuable reagent in organic synthesis, particularly for the derivatization of carbonyl compounds. It is widely employed in analytical chemistry and as a building block in the preparation of various heterocyclic compounds and pharmaceuticals.
- IUPAC
- N-Aminourea hydrochloride,Hydrazine carboxamide hydrochloride
- Synonyms
- N-Aminourea hydrochlorideHydrazine carboxamide hydrochloride

Carbonyl Compound Derivatization
Semicarbazide hydrochloride reacts with aldehydes and ketones to form semicarbazones. This reaction is often used for the identification and characterisation of carbonyl compounds due to the typically crystalline nature and sharp melting points of the resulting semicarbazones.
Organic Synthesis Intermediate
It functions as a key intermediate in the synthesis of various organic molecules, including pharmaceuticals and heterocyclic compounds. Its structure allows for diverse chemical transformations, making it a versatile building block for complex molecular architectures.
Analytical Reagent
Utilised in analytical laboratories for specific chemical tests and separations. Its ability to form stable derivatives aids in the qualitative and quantitative analysis of certain functional groups within a sample.
| Molecular weight | 111.53 |
|---|---|
| Linear formula | NH2CONHNH2 · HCl |
| Assay | ≥99% |
| Melting point | 175-177 °C (dec.)(lit.) |

Hazard statements
- H301Toxic if swallowed
Precautionary statements
- P301IF SWALLOWED
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25 |
| Safety statements (S) | 45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Semicarbazide hydrochloride used for?
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Semicarbazide hydrochloride is primarily used for the derivatisation of carbonyl compounds (aldehydes and ketones) to form semicarbazones, which aids in their identification and characterisation. It also serves as an intermediate in organic synthesis, particularly for creating heterocyclic compounds and pharmaceuticals.
What is the CAS number and formula for Semicarbazide hydrochloride?
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The CAS number for Semicarbazide hydrochloride is 563-41-7, and its linear formula is NH₂CONHNH₂ · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Semicarbazide hydrochloride with an assay of ≥99%. We do not represent this product as USP, BP, or EP grade unless explicitly stated in the product documentation.
How should Semicarbazide hydrochloride be handled safely?
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Semicarbazide hydrochloride is classified as toxic if swallowed (H301). Handling requires appropriate personal protective equipment, including eyeshields, face shields, gloves, and P2 respirator cartridges. Ensure adequate ventilation and avoid ingestion. Refer to the Safety Data Sheet for comprehensive handling and emergency procedures.
Is Semicarbazide hydrochloride a controlled substance?
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Based on the provided data, Semicarbazide hydrochloride is not listed as a controlled substance. However, users should always verify compliance with local and international regulations.
How is Semicarbazide hydrochloride packed and shipped?
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Semicarbazide hydrochloride is typically packed in accordance with UN 2811 regulations for transport of toxic solids. TSS adheres to all international shipping and export regulations for chemical compounds.
How can I request a sample or quote for Semicarbazide hydrochloride?
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To request a sample or a quote for Semicarbazide hydrochloride, please contact our sales team through the website or by phone, providing your specific requirements and delivery location.
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