Semustine
Semustine (CAS: 13909-09-6, C10H18ClN3O2) is a chemical compound with a molecular weight of 247.72. It is primarily utilised in pharmacological research, particularly in studies related to nutrient-sensitized drug screening for metabolic pathway shifts and as part of the CEOP chemotherapy regimen for lymphoma patients. Its potential applications in chemotherapy investigations are also a significant area of research.
- IUPAC
- N-(2-Chloroethyl)-N′-(4-methylcyclohexyl)-N-nitrosourea,Methyl-CCNU
- Synonyms
- Methyl-CCNU
Pharmacological Research
Utilised in nutrient-sensitized screening to identify drugs that alter cellular energy metabolism, shifting from mitochondrial respiration to glycolysis. This helps in understanding drug mechanisms and developing new therapeutic strategies.
Chemotherapy Regimens
Incorporated into the CEOP regimen as induction chemotherapy for patients diagnosed with lymphoma. Its use is investigated for its efficacy in treating specific types of cancer.
Drug Development Investigations
Explored for its therapeutic potential in various chemotherapy applications. Ongoing research aims to elucidate its mechanisms of action and broaden its clinical applicability.
| Molecular weight | 247.72 |
|---|---|
| Empirical formula | C10H18ClN3O2 |
| Application | Commonly used in pharmacological studies involving: • Nutrient-sensitized screening for drugs that shift the energy metabolism from mitchondrial respiration to glycolysis1• CEOP regimen with semustine used as induction chemotherapy in patients with lymphoma2• Investigations into its use for chemotherapy3,4 |
Hazard statements
- H300Fatal if swallowed
- H311Toxic in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H331Toxic if inhaled
- H335May cause respiratory irritation
- H350May cause cancer
- H360May damage fertility or the unborn child
Precautionary statements
- P201Obtain special instructions before use
- P261Avoid breathing dust, fume, gas or vapours
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 45-46-23/24/25-36/37/38 |
| Safety statements (S) | 53-22-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Semustine used for?
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Semustine is used in pharmacological studies for nutrient-sensitized screening of drugs affecting cellular energy metabolism, as part of the CEOP chemotherapy regimen for lymphoma, and for investigations into its use in chemotherapy.
What are the CAS number and formula for Semustine?
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The CAS number for Semustine is 13909-09-6, and its empirical formula is C10H18ClN3O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Semustine as a research-grade chemical. We do not represent this product as USP, BP, or EP grade.
How should Semustine be handled and stored safely?
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Semustine is classified as Dangerous, with hazards including acute toxicity (oral, dermal, inhalation), skin and eye irritation, and potential carcinogenicity and reproductive toxicity. Handle with extreme care using appropriate personal protective equipment (e.g., gloves, eyeshields, respirator) in a well-ventilated area. Store in accordance with safety data sheet guidelines.
Is Semustine a controlled substance?
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The provided data does not indicate that Semustine is a controlled substance.
How is Semustine shipped and exported?
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Semustine is shipped as UN 2811, Hazard Class 6.1, Packing Group II, adhering to strict international regulations for hazardous material transport. TSS is a specialist global supplier and exporter.
How can I request a sample or quote for Semustine?
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To request a sample or quote for Semustine, please contact our sales team through the TSS website or by phone.
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