PD153035 hydrochloride
PD153035 hydrochloride (CAS: 183322-45-4) is a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. With the molecular formula C16H14BrN3O2 · HCl and a molecular weight of 396.67 g/mol, this white to beige powder is primarily utilized in cell biology research for investigating signaling pathways. Its applications extend to studying receptor tyrosine kinase function and developing targeted therapies.
- IUPAC
- 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride,AG 1517,PD 153035,SU 5271,ZM 252868
- Synonyms
- 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochlorideAG 1517PD 153035SU 5271ZM 252868
EGFR Kinase Inhibition
PD153035 hydrochloride serves as a critical tool for researchers studying the role of EGFR in cellular processes. It selectively inhibits EGFR tyrosine kinase activity, allowing for the investigation of downstream signaling pathways.
Receptor Tyrosine Kinase Research
This compound is valuable for in-depth studies of receptor tyrosine kinase (RTK) biology. Its specific action on EGFR contributes to understanding RTK-mediated cell growth, differentiation, and survival.
Cell Signaling Pathway Analysis
Researchers employ PD153035 hydrochloride to dissect complex cell signaling networks. By blocking EGFR, it helps elucidate the impact of this receptor on various cellular responses.
Neuroscience Research Tool
Within neuroscience, PD153035 hydrochloride can be used to explore the involvement of EGFR signaling in neuronal function and development, contributing to a broader understanding of neurological processes.
| Molecular weight | 396.67 |
|---|---|
| Empirical formula | C16H14BrN3O2 · HCl |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white to beige |
| Solubility | DMSO: soluble2 mg/mL, clear (warmed) |
| Storage temperature | 2-8°C |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-37/38-41 |
| Safety statements (S) | 26-39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is PD153035 hydrochloride used for?
+
PD153035 hydrochloride is primarily used in cell biology research as a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. It is valuable for studying cell signaling pathways, receptor tyrosine kinase biology, and neuroscience research.
What are the CAS number and formula for PD153035 hydrochloride?
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The CAS number for PD153035 hydrochloride is 183322-45-4, and its empirical formula (Hill notation) is C16H14BrN3O2 · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies PD153035 hydrochloride with an assay of ≥98% (HPLC). This product is intended for research purposes; TSS does not represent it as USP, EP, BP, or pharmacopoeia grade.
How should PD153035 hydrochloride be handled safely?
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PD153035 hydrochloride is classified as Danger with hazards including H301 (Toxic if swallowed), H315 (Causes skin irritation), H318 (Causes serious eye damage), and H335 (May cause respiratory irritation). Handle with appropriate personal protective equipment (gloves, eye protection, respiratory protection) in a well-ventilated area. Avoid ingestion, skin contact, and inhalation.
Is PD153035 hydrochloride shipped internationally?
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Yes, Tech Serve Solutions, as a specialist global supplier and exporter, ships PD153035 hydrochloride worldwide.
How can I request a quote or sample for PD153035 hydrochloride?
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To request a quote or a sample of PD153035 hydrochloride, please contact our sales team through the website or by phone. Please specify the quantity required.
What is the recommended storage temperature for PD153035 hydrochloride?
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PD153035 hydrochloride should be stored at 2-8°C to maintain its stability and efficacy.
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