PD-184161

CAS 212631-67-9C17H13BrClF2IN2O2Cell Biology

PD-184161 (CAS: 212631-67-9) is a research chemical compound with a molecular weight of 557.56 and empirical formula C17H13BrClF2IN2O2. It is supplied as a white to off-white powder. This compound is primarily utilised in biological research, particularly within cell biology and kinase/phosphatase signalling pathways. It is a selective inhibitor of MEK1/2, making it a valuable tool for studying cellular responses to mitogen-activated protein kinase (MAPK) cascade activation.

IUPAC: 5-Bromo-2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-benzamide,PF-1529483,PF-3011370,UK-287074
Synonyms: 5-Bromo-2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-benzamidePF-1529483PF-3011370UK-287074

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PD-184161 (C17H13BrClF2IN2O2) — chemical structure, CAS 212631-67-9; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesCell BiologyKinase/Phosphatase BiologyPfizer Compounds

01 /Applications

MEK Inhibitor for Cell Signalling Research

PD-184161 functions as a potent and selective inhibitor of MEK1 and MEK2, key kinases in the MAPK pathway. This makes it an invaluable research tool for investigating cellular proliferation, differentiation, and survival mechanisms.

Investigating MAPK Pathway Dysregulation

Its specific action on MEK kinases allows researchers to study the role of this signalling cascade in various biological processes and disease states, including cancer and neurological disorders.

Drug Discovery and Development

As a known drug candidate, PD-184161 serves as a reference compound or starting point in the development of novel therapeutics targeting aberrant MAPK signalling.

02 /Properties

Molecular weight	557.56
Empirical formula	C17H13BrClF2IN2O2
Assay	≥98% (HPLC)
Form	powder
Colour	white to off-white
Solubility	DMSO: >10 mg/mL
Storage temperature	2-8°C

03 /Safety & handling

GHS hazard pictogram: Environmental hazard (GHS09) — Environmental hazard

Warning

Hazard statements

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment

Transport (UN / ADR)	UN 3077 9 / PGIII
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

212631-67-9

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is PD-184161 used for?

PD-184161 is used in research as a selective inhibitor of MEK1/2 kinases, primarily for studying cell signalling pathways, including the MAPK cascade, in areas such as cell biology and neuroscience.

What are the CAS number and formula for PD-184161?

The CAS number for PD-184161 is 212631-67-9, and its empirical formula is C17H13BrClF2IN2O2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies PD-184161 with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.

How should PD-184161 be handled and stored?

PD-184161 is classified with GHS09 and the signal word 'Warning', carrying hazard statement H400 (Very toxic to aquatic life). It should be handled with appropriate precautions to avoid environmental release (P273). Store at 2-8°C.

Is PD-184161 available for export?

Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including PD-184161, adhering to all relevant shipping regulations (UN 3077 9 / PGIII).