Maleimide-PEG8-succinimidyl ester
Maleimide-PEG8-succinimidyl ester (CAS: 756525-93-6), with the empirical formula C30H47N3O15 and a molecular weight of 689.71 g/mol, is a heterobifunctional crosslinker. It features a maleimide group reactive towards sulfhydryls and an N-hydroxysuccinimide (NHS) ester group reactive towards primary amines. The polyethylene glycol (PEG) spacer offers solubility and reduces non-specific binding. This compound is primarily utilised in bioconjugation for linking biomolecules.
- IUPAC
- 31-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-29-oxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacontanoic acid 2,5-dioxo-1-pyrrolidinyl ester,31-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-29-oxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacontanoic acid 2,5-dioxo-1-pyrrolidinyl ester,Maleimide PEG8 succinimidyl ester,Maleimide-PEG8-NHS ester,Maleimide-PEG8-NHS ester
- Synonyms
- Maleimide PEG8 succinimidyl esterMaleimide-PEG8-NHS ester31-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-29-oxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacontanoic acid 2,5-dioxo-1-pyrrolidinyl ester
Bioconjugation and Labeling
Utilised to conjugate amine-containing biomolecules (via the NHS ester) to sulfhydryl-containing biomolecules (via the maleimide group). The PEG linker enhances water solubility and can reduce steric hindrance.
Surface Modification
Can be employed to modify surfaces functionalised with amines or thiols, enabling the subsequent attachment of other molecules or the creation of specific surface properties for biosensing or biomaterial applications.
Protein Crosslinking
Facilitates the formation of covalent bonds between proteins or peptides, allowing for the study of protein-protein interactions or the stabilisation of protein structures.
| Molecular weight | 689.71 |
|---|---|
| Empirical formula | C30H47N3O15 |
| Storage temperature | −20°C |
| Application | Heterobifunctional crosslinker with an ethylene oxide spacer for linking amine- to sulfhydryl-containing compounds or biomolecules. Maleimide functional group will react with sulfhydryls and the succinimidyl ester group will react with amines. Spacer length is 39.2 angstroms. |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Maleimide-PEG8-succinimidyl ester used for?
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Maleimide-PEG8-succinimidyl ester is a heterobifunctional crosslinker used in bioconjugation for linking amine- and sulfhydryl-containing compounds or biomolecules. Its maleimide group reacts with thiols, and its NHS ester reacts with amines, bridged by a PEG8 spacer.
What is the CAS number and empirical formula for Maleimide-PEG8-succinimidyl ester?
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The CAS number is 756525-93-6, and the empirical formula is C30H47N3O15.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound for research and chemical synthesis purposes. The specific assay and purity are detailed in the product's Certificate of Analysis. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should Maleimide-PEG8-succinimidyl ester be handled and stored?
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This compound is classified under WGK Germany 3. It should be handled with appropriate personal protective equipment in a well-ventilated area. Store refrigerated at -20°C as indicated for optimal stability.
Is Maleimide-PEG8-succinimidyl ester a controlled substance?
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The provided data does not indicate that Maleimide-PEG8-succinimidyl ester is a controlled substance.
How are products like Maleimide-PEG8-succinimidyl ester packed, shipped, and exported?
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Products are carefully packed according to international shipping regulations for chemicals. Tech Serve Solutions has extensive experience in exporting fine chemicals globally.
How can I request a sample or quote for Maleimide-PEG8-succinimidyl ester?
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Please contact our sales department via the website or by phone to request a sample or a formal quotation for Maleimide-PEG8-succinimidyl ester.
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