Maleimide-PEG12-succinimidyl ester
Maleimide-PEG12-succinimidyl ester (CAS: 1426151-00-9) is a heterobifunctional crosslinker with the empirical formula C38H63N3O19 and a molecular weight of 865.92. It features a maleimide group reactive towards sulfhydryls and a succinimidyl ester group reactive towards amines, separated by a 12-unit polyethylene glycol (PEG) spacer. This PEG linker provides hydrophilicity and a defined length of 53.3 angstroms, making it suitable for bioconjugation and chemical synthesis applications.
- IUPAC
- 2,5-Dioxopyrrolidin-1-yl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28,31,34,37,40-dodecaoxa-4-azatritetracontan-43-oate,2,5-Dioxopyrrolidin-1-yl-1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28,31,34,37,40-dodecaoxa-4-azatritetracontan-43-oate,Maleimide PEG12 succinimidyl ester,Maleimide-PEG12-NHS ester,Maleimide-PEG12-NHS este
- Synonyms
- 2,5-Dioxopyrrolidin-1-yl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28,31,34,37,40-dodecaoxa-4-azatritetracontan-43-oate,Maleimide PEG12 succinimidyl ester,Maleimide-PEG12-NHS ester
Bioconjugation
This crosslinker is employed to covalently link biomolecules or surfaces containing amine groups to those containing sulfhydryl groups. The PEG spacer enhances solubility and reduces non-specific binding.
Surface Modification
It can be used to functionalise surfaces, immobilising amine-containing molecules onto sulfhydryl-modified substrates or vice versa, facilitating the development of biosensors and diagnostic tools.
Chemical Synthesis
As a building block in organic synthesis, it enables the precise introduction of maleimide and activated ester functionalities into complex molecular architectures, mediated by the PEG chain.
Drug Delivery Systems
The heterobifunctional nature and PEG linker are advantageous in developing targeted drug delivery conjugates, allowing for the attachment of therapeutic agents to targeting ligands.
| Molecular weight | 865.92 |
|---|---|
| Empirical formula | C38H63N3O19 |
| Storage temperature | −20°C |
| Application | Heterobifunctional crosslinker with an ethylene oxide spacer for linking amine- to sulfhydryl-containing compounds or biomolecules. Maleimide functional group will react with sulfhydryls and the succinimidyl ester group will react with amines. Spacer length is 53.3 angstroms. |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Maleimide-PEG12-succinimidyl ester used for?
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Maleimide-PEG12-succinimidyl ester is primarily used as a heterobifunctional crosslinker to link amine- to sulfhydryl-containing compounds or biomolecules. The maleimide group reacts with sulfhydryls, and the succinimidyl ester group reacts with amines.
What are the CAS number and formula for Maleimide-PEG12-succinimidyl ester?
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The CAS number is 1426151-00-9, and the empirical formula is C38H63N3O19.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product for research and laboratory use. The specific assay and purity are detailed in the product's Certificate of Analysis. We do not represent this product as USP, BP, or EP grade.
How should Maleimide-PEG12-succinimidyl ester be handled and stored?
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Handle with appropriate personal protective equipment. Refer to the Safety Data Sheet (SDS) for detailed handling instructions. It should be stored at -20°C.
Is this chemical a controlled substance?
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The provided data does not indicate that this compound is a controlled substance.
How is this product packed, shipped, and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. Packaging and shipping methods comply with international regulations for chemical transport. Please contact us for specific export inquiries.
How can I request a sample or quote?
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Samples and quotes can be requested through the Tech Serve Solutions website or by contacting our sales department directly. Please provide the product name and CAS number for prompt service.
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