Maleimide-PEG2-succinimidyl ester
Maleimide-PEG2-succinimidyl ester (CAS: 955094-26-5, C18H23N3O9) is a heterobifunctional crosslinker from Tech Serve Solutions. It features a maleimide group for reaction with sulfhydryls and a succinimidyl ester for amines, connected by a short ethylene oxide spacer (17.6 Å). This compound is primarily utilised in chemical biology and synthesis for conjugation applications, enabling the precise linking of biomolecules and other chemical entities.
- IUPAC
- 3-[2-[2-[[3-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]ethoxy]ethoxy]propanoic acid 2,5-dioxo-1-pyrrolidinyl ester,Maleimide-PEG2-NHS
Bioconjugation
Utilised to covalently link molecules containing amine groups (via the NHS ester) to molecules containing sulfhydryl groups (via the maleimide group). This is crucial for antibody-drug conjugates, protein labelling, and immobilisation.
Peptide and Protein Modification
Enables targeted modification of peptides and proteins by introducing specific functional groups or creating crosslinks. The PEG spacer can improve solubility and reduce immunogenicity of conjugates.
Surface Functionalisation
Can be used to functionalise surfaces that have amine or sulfhydryl groups, preparing them for subsequent binding events or assays in biosensor development and material science.
Drug Delivery Systems
As a linker component in drug delivery systems, it facilitates the conjugation of therapeutic agents to targeting moieties or delivery vehicles.
| Molecular weight | 425.39 |
|---|---|
| Empirical formula | C18H23N3O9 |
| Assay | 99% |
| Storage temperature | −20°C |
| Application | Heterobifunctional crosslinker with short ethylene oxide spacer for linking amine- to sulfhydryl-containing compounds or biomolecules. Maleimide functional group will react with sulfhydryls and the succinimidyl ester group will react with amines. Spacer length is 17.6 angstroms. |
| Melting point | 92-94 °C |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Maleimide-PEG2-succinimidyl ester used for?
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Maleimide-PEG2-succinimidyl ester is a heterobifunctional crosslinker used to link amine- to sulfhydryl-containing compounds or biomolecules. The maleimide group reacts with sulfhydryls, and the succinimidyl ester reacts with amines.
What is the CAS number and formula for Maleimide-PEG2-succinimidyl ester?
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The CAS number is 955094-26-5 and the molecular formula is C18H23N3O9.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Maleimide-PEG2-succinimidyl ester with an assay of 99%. It is supplied for research and development purposes and is not intended for use as USP, BP, EP, or any pharmacopoeia grade.
What are the safety and handling considerations for Maleimide-PEG2-succinimidyl ester?
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Maleimide-PEG2-succinimidyl ester is classified under WGK Germany 3, indicating it is hazardous to water. Appropriate personal protective equipment, including gloves and eye protection, should be used when handling. It should be stored at -20°C.
How is Maleimide-PEG2-succinimidyl ester packed and shipped?
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This chemical is carefully packed according to international shipping regulations and can be exported globally by Tech Serve Solutions.
How can I request a sample or quote for Maleimide-PEG2-succinimidyl ester?
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You can request a sample or a quote by contacting the Tech Serve Solutions sales team through our website or by calling us directly.
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