Morpholine
Morpholine (CAS 110-91-8) is a heterocyclic organic compound with the molecular formula C4H9NO and a molar mass of 87.12 g/mol. A colourless, hygroscopic liquid combining an amine and an ether function in a six-membered ring, it is a versatile, strongly basic building block. Tech Serve Solutions supplies high-purity Morpholine (≥99.5% by GC) as a synthesis intermediate, corrosion inhibitor and reagent for fine-chemical, pharmaceutical and industrial applications worldwide.
- IUPAC
- Tetrahydro-1,4-oxazine
- Synonyms
- MorpholineTetrahydro-1,4-oxazine1-Oxa-4-azacyclohexaneDiethylene oximideTetrahydro-2H-1,4-oxazineCAS 110-91-8
Pharmaceutical and fine-chemical synthesis
Morpholine is a widely used heterocyclic building block for introducing the morpholine ring into active pharmaceutical ingredients, agrochemicals and other fine chemicals. Its secondary amine readily forms amides, sulfonamides and substituted derivatives.
Corrosion inhibition and boiler water treatment
As a volatile, neutralising amine, Morpholine is used to control pH and inhibit corrosion in steam and boiler-water systems. It distributes between water and vapour phases to protect condensate lines.
Rubber and polymer chemistry
Morpholine serves as an intermediate in the manufacture of rubber vulcanisation accelerators and other processing chemicals. It is also employed as a building block in the preparation of certain surfactants and optical brighteners.
Solvent and reaction medium
Its combined amine and ether character makes Morpholine a useful basic solvent and catalyst in organic reactions, including enamine formation and acid-scavenging steps in laboratory and process chemistry.
Research reagent
Supplied at ≥99.5% purity, Morpholine is suitable as a laboratory reagent for method development, synthesis and analytical work where a defined, high-purity grade is required.
| Molecular weight | 87.12 |
|---|---|
| Empirical formula | C4H9NO |
| Assay | ≥99.5% (GC) |
| Boiling point | 129 °C(lit.) |
| Density | 0.996 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.453-1.455n20/D 1.454(lit.) |
| Vapour pressure | 31 mmHg (38 °C)7 mmHg (20 °C) |
| Melting point | −7-−5 °C(lit.) |
| Vapour density | 3 (vs air) |
| Autoignition temp | 590 °F |
Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H314Causes severe skin burns and eye damage
- H332Harmful if inhaled
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 31 °C / 87.8 °F |
| Transport (UN / ADR) | UN 2054 3(8) / PGI |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | C |
| Risk statements (R) | 10-20/21/22-34 |
| Safety statements (S) | 23-36-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Morpholine used for?
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Morpholine is used principally as a building block in pharmaceutical, agrochemical and fine-chemical synthesis, as a neutralising amine and corrosion inhibitor in boiler-water and steam systems, as an intermediate for rubber accelerators and surfactants, and as a basic solvent or catalyst in organic reactions.
What is the CAS number and molecular formula of Morpholine?
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Morpholine has the CAS number 110-91-8 and the molecular formula C4H9NO, with a molecular weight of 87.12 g/mol. It is also identified by EC number 203-815-1, MDL number MFCD00005972 and the synonym tetrahydro-1,4-oxazine.
What grade and purity of Morpholine does Tech Serve Solutions supply?
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Tech Serve Solutions supplies high-purity Morpholine with an assay of ≥99.5% determined by gas chromatography (GC), as a technical/reagent-grade product. We do not represent it as USP, BP or EP pharmacopoeial grade; a Certificate of Analysis is provided with each batch.
What are the safety and handling hazards of Morpholine?
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Morpholine is classified as Danger (GHS02, GHS05, GHS07). It is a flammable liquid and vapour (H226), is harmful if swallowed, in contact with skin or if inhaled (H302, H312, H332), and causes severe skin burns and eye damage (H314). Handle away from heat and ignition sources with full skin, eye and respiratory protection (gloves, goggles, face shield and a suitable ABEK respirator), and keep containers tightly closed. Consult the Safety Data Sheet before use.
How is Morpholine packed, shipped and exported?
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Morpholine is supplied in tightly sealed, compatible containers appropriate to the order quantity and to its classification as a hazardous good. It is shipped as UN 2054, Class 3 (8), Packing Group I under ADR/IMDG/IATA rules, with full documentation, labelling and a Safety Data Sheet for compliant domestic and international export.
How do I request a sample or quote for Morpholine?
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Contact Tech Serve Solutions with your required quantity, grade and destination, and our team will respond with availability, lead time, documentation and a formal quotation. Samples can be arranged on request, subject to transport and regulatory requirements for this hazardous material.
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