Methyl α-oxo-7-azaindole-3-acetate
Methyl α-oxo-7-azaindole-3-acetate (CAS 357263-49-1) is a 7-azaindole-based heterocyclic building block with the molecular formula C10H8N2O3 and a molar mass of 204.18 g/mol. Also described as methyl oxo-(1H-pyrrolo[2,3-b]pyridin-3-yl)-acetate, it combines a reactive α-keto ester with a pyrrolo[2,3-b]pyridine core. Tech Serve Solutions supplies it as a research-grade reagent for chemical synthesis and pharmaceutical-intermediate work, principally as an intermediate in the preparation of substituted azaindole derivatives.
- IUPAC
- Oxo-(1H-pyrrolo[2,3-b]pyridin-3-yl)-acetic acid methyl ester
- Synonyms
- Methyl α-oxo-7-azaindole-3-acetateMethyl oxo-(1H-pyrrolo[2,3-b]pyridin-3-yl)-acetateOxo-(1H-pyrrolo[2,3-b]pyridin-3-yl)-acetic acid methyl esterMethyl 2-(1H-pyrrolo[2,3-b]pyridin-3-yl)-2-oxoacetateα-Oxo-7-azaindole-3-acetic acid methyl esterCAS 357263-49-1
7-Azaindole building block
Serves as a heterocyclic building block based on the 1H-pyrrolo[2,3-b]pyridine (7-azaindole) scaffold, a privileged motif widely used in medicinal chemistry and the construction of nitrogen-containing ring systems.
Pharmaceutical intermediate synthesis
Used as an intermediate in multi-step routes toward azaindole-derived candidate molecules. The 7-azaindole core appears in numerous biologically active compounds and kinase-directed scaffolds.
α-Keto ester reactivity
The reactive α-oxo (2-oxoacetate) ester group offers a versatile handle for condensation, reduction and reductive amination, enabling onward elaboration to α-hydroxy esters, α-amino acids and related derivatives.
Research and discovery chemistry
Suited to laboratory-scale synthesis, library design and structure-activity exploration where a functionalised azaindole acetate is required as a starting material.
| Molecular weight | 204.18 |
|---|---|
| Empirical formula | C10H8N2O3 |
| Assay | 97% |
| Melting point | 170-172 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl α-oxo-7-azaindole-3-acetate used for?
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It is used principally as a heterocyclic building block and pharmaceutical intermediate. Built on the 7-azaindole (1H-pyrrolo[2,3-b]pyridine) scaffold and bearing a reactive α-keto ester, it is a starting material for synthesising substituted azaindole derivatives in research and discovery chemistry.
What is the CAS number and molecular formula of Methyl α-oxo-7-azaindole-3-acetate?
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Its CAS number is 357263-49-1 and its molecular formula is C10H8N2O3, with a molecular weight of 204.18 g/mol. It is also known as methyl oxo-(1H-pyrrolo[2,3-b]pyridin-3-yl)-acetate.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product at a typical assay of 97%, as a research/technical-grade reagent for chemical synthesis. We do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis can be provided with each batch on request.
What safety and handling precautions apply?
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Handle as a laboratory chemical using good practice. Recommended personal protective equipment includes eye shields, gloves and an N95 (US) or P1 (EN143) respirator filter to avoid dust formation and contact. The substance is classified WGK 3 (highly hazardous to water in Germany), so prevent release to drains, soil and waterways. Always consult the Safety Data Sheet before use.
How is Methyl α-oxo-7-azaindole-3-acetate packed, shipped and exported?
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It is packed as a solid in sealed, labelled containers sized to the order, from gram quantities upward, with appropriate protective and tamper-evident packaging. Tech Serve Solutions exports worldwide with full documentation, including the certificate of analysis and Safety Data Sheet, in line with applicable transport regulations.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and destination, quoting CAS 357263-49-1 and product reference 114631. Our team will respond with availability, lead time, packing options and a formal quotation, and can arrange a sample where appropriate.
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