Muscimol
Muscimol (CAS 2763-96-4) is an isoxazole-derived bioactive small molecule with the molecular formula C4H6N2O2 and a molar mass of 114.10 g/mol. The principal psychoactive constituent of Amanita muscaria, it is a potent, selective agonist of the GABA-A receptor and a structural analogue of the neurotransmitter GABA. Tech Serve Solutions supplies muscimol as a research-grade reagent for neuroscience, receptor pharmacology and cell-biology studies. It is highly toxic and handled accordingly.
- IUPAC
- 3-Hydroxy-5-aminomethyl-isoxazole,5-Aminomethyl-3-hydroxy-isoxazole,5-Aminomethyl-3-isoxazolol
- Synonyms
- Muscimol3-Hydroxy-5-aminomethyl-isoxazole5-Aminomethyl-3-hydroxy-isoxazole5-Aminomethyl-3-isoxazolol5-(Aminomethyl)-3-isoxazolol5-(Aminomethyl)isoxazol-3-olAgarinPantherine
GABA-A receptor research
Muscimol is a potent, selective agonist of the GABA-A receptor and is widely used as a reference pharmacological tool to probe GABAergic signalling and inhibitory neurotransmission in vitro and in tissue preparations.
Neuroscience and electrophysiology
It is employed in neuroscience studies of synaptic inhibition, ion-channel function and receptor binding, where a well-characterised GABA analogue is required as a positive control or probe.
Cell biology and pharmacology
As a bioactive small molecule, muscimol serves in cell-biology and receptor-pharmacology assays investigating GABA-A receptor subunits and downstream chloride-channel activity.
Heterocyclic building block and reference standard
The isoxazole scaffold makes muscimol useful as a heterocyclic building block in chemical synthesis and as an analytical reference standard for identification and method development.
| Molecular weight | 114.10 |
|---|---|
| Empirical formula | C4H6N2O2 |
| Storage temperature | 2-8°C |
Hazard statements
- H300Fatal if swallowed
Precautionary statements
- P264Wash thoroughly after handling
- P301IF SWALLOWED
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 1544 6.1/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25 |
| Safety statements (S) | 22-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | rat ... Gabra2(29706) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Muscimol used for?
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Muscimol is used principally in research as a potent, selective GABA-A receptor agonist. It is applied in neuroscience, electrophysiology, receptor pharmacology and cell-biology studies of GABAergic inhibitory signalling, and it can serve as a heterocyclic isoxazole building block and analytical reference standard.
What is the CAS number and molecular formula of Muscimol?
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Muscimol has the CAS number 2763-96-4 and the molecular formula C4H6N2O2, with a molecular weight of 114.10 g/mol. Its MDL number is MFCD00057894, its EC number is 220-430-4 and its Beilstein registry number is 1618960.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies muscimol as a research-grade reagent suitable for laboratory and pharmacological research. We do not represent this material as USP, BP or EP pharmacopoeial grade. A current specification and certificate of analysis are provided with each batch; please request these for exact assay values.
What are the safety and handling requirements for Muscimol?
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Muscimol is classified GHS06 with the signal word Danger and hazard statement H300 (fatal if swallowed); under the older European system it is toxic (T). It must be handled only by trained personnel using eye and face protection, gloves and a type P2 (EN 143) respirator, with measures to avoid ingestion (P264, P301 + P310). Store at 2-8°C in a tightly closed container.
How is Muscimol packed, shipped and exported?
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Muscimol is supplied in laboratory-appropriate quantities, sealed and labelled to international standards with full documentation. It is classified for transport as UN 1544, Class 6.1, Packing Group II, and is shipped under applicable dangerous-goods regulations. Tech Serve Solutions exports worldwide with cold-chain or temperature-controlled handling on request, subject to destination import rules.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, packaging and destination, and we will respond with availability, current specifications, lead time and a formal quotation. Samples and certificates of analysis can be arranged on request, subject to regulatory and dangerous-goods requirements.
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