Fmoc-Glu(OtBu)-OH
Fmoc-Glu(OtBu)-OH (CAS 71989-18-9), with the molecular formula C24H27NO6 and a molecular weight of 425.47 g/mol, is a protected derivative of L-glutamic acid. It features the Fmoc protecting group on the alpha-amino group and a tert-butyl ester on the side-chain carboxyl group. This compound is essential in solid-phase peptide synthesis (SPPS) for the controlled incorporation of glutamic acid residues into peptide chains.
- IUPAC
- Fmoc-L-glutamic acid 5-tert-butyl ester
Solid-Phase Peptide Synthesis (SPPS)
Fmoc-Glu(OtBu)-OH is widely used in SPPS to introduce glutamic acid residues. The tert-butyl ester protects the gamma-carboxyl group of glutamic acid, preventing side reactions during peptide chain elongation while the Fmoc group allows for facile deprotection under basic conditions.
Chemical Biology Research
This derivative finds application in chemical biology for constructing peptides with specific side-chain functionalities. It enables researchers to synthesize modified peptides for studying protein-protein interactions, enzyme mechanisms, and developing peptide-based therapeutics.
Organic Synthesis
Beyond peptide synthesis, Fmoc-Glu(OtBu)-OH serves as a valuable building block in complex organic synthesis. Its protected functional groups allow for selective chemical transformations, contributing to the synthesis of diverse organic molecules and intermediates.
| Molecular weight | 425.47 |
|---|---|
| Empirical formula | C24H27NO6 |
| Assay | ≥98.0% (HPLC) |
| Optical activity | [α]20/D −5.0±2.0°, c = 1% in acetic acid: water (4:1) |
| Storage temperature | 2-8°C |
| Impurities tested | ~4% water |
| Melting point | 83-90 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Glu(OtBu)-OH used for?
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Fmoc-Glu(OtBu)-OH is primarily used in solid-phase peptide synthesis (SPPS) for the incorporation of protected glutamic acid residues into peptide sequences. It is also a key building block in chemical biology research and organic synthesis.
What is the CAS number and molecular formula for Fmoc-Glu(OtBu)-OH?
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The CAS number for Fmoc-Glu(OtBu)-OH is 71989-18-9, and its molecular formula is C24H27NO6.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Glu(OtBu)-OH with a purity of ≥98.0% (HPLC). This product is intended for research and chemical synthesis purposes and is not supplied as USP, BP, EP, or pharmaceutical grade.
What are the safety and handling recommendations for Fmoc-Glu(OtBu)-OH?
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Handling Fmoc-Glu(OtBu)-OH requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Store at 2-8°C. It is classified with WGK Germany 3.
How is Fmoc-Glu(OtBu)-OH packed, shipped, and exported?
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Tech Serve Solutions expertly packs, ships, and exports fine chemicals globally, adhering to all necessary regulations for safe and compliant international transit. Specific packaging details can be provided upon request.
How can I request a sample or quote for Fmoc-Glu(OtBu)-OH?
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To request a sample or a detailed quote for Fmoc-Glu(OtBu)-OH, please contact our sales team via the website or direct inquiry. Our specialists will assist you promptly.
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