(−)-2,3-O-Isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane
(−)-2,3-O-Isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane (CAS 32305-98-9) is a chiral diphosphine ligand with the molecular formula C31H32O2P2 and a molecular weight of 498.53 g/mol. This compound is primarily utilised in asymmetric synthesis for the in situ preparation of chiral hydrogenation catalysts. Its specific stereochemistry and phosphine functionalities make it valuable in stereoselective catalytic processes within chemical synthesis and for creating advanced chiral ligands.
- IUPAC
- (−)-1,4-Bis(diphenylphosphino)-1,4-dideoxy-2,3-O-isopropylidene-L-threitol,(4R,5R)-4,5-Bis(diphenylphosphino-methyl)-2,2-dimethyl-1,3-dioxolane,(4R-trans)-[(2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene)]bis(diphenylphosphine),(R,R)-DIOP
- Synonyms
- 4-bis(diphenylphosphino)butaneDIOP(R,R)-DIOP(4R,5R)-4,5-Bis(diphenylphosphino-methyl)-2,2-dimethyl-1,3-dioxolane
Asymmetric Hydrogenation
Used in the preparation of chiral hydrogenation catalysts, enabling stereoselective reduction of prochiral substrates to enantiomerically enriched products.
Chiral Ligand Synthesis
Serves as a key building block for the synthesis of more complex chiral ligands and catalyst systems used in fine chemical and pharmaceutical synthesis.
Catalysis Research
Employed in academic and industrial research for developing novel catalytic methodologies and exploring new asymmetric transformations.
| Molecular weight | 498.53 |
|---|---|
| Empirical formula | C31H32O2P2 |
| Assay | 98% |
| Optical activity | [α]19/D −26°, c = 2.3 in chloroform |
| Storage temperature | 2-8°C |
| Application | For the in situ preparation of chiral hydrogenation catalysts. |
| Melting point | 88-90 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (–)-2,3-O-Isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane used for?
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(–)-2,3-O-Isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane is used for the in situ preparation of chiral hydrogenation catalysts, finding applications in asymmetric synthesis and chemical research.
What is the CAS number and formula for this compound?
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The CAS number is 32305-98-9, and the empirical formula is C31H32O2P2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of 98%. It is not represented as USP, BP, or EP grade.
How should this chemical be handled safely?
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This chemical is a warning hazardous substance. Handle with appropriate personal protective equipment including a dust mask (N95 type), eyeshields, and gloves. Ensure good ventilation to avoid inhalation of dust. Avoid contact with skin and eyes, and do not ingest.
How is this product shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, capable of shipping and exporting this product worldwide while adhering to all relevant regulations.
How can I request a sample or quote?
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To request a sample or a quote for (–)-2,3-O-Isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane, please contact our sales team through the website or by phone.
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