Fmoc-D-Phe(2-CF3)-OH

CAS 352523-15-0C25H20F3NO4Chemical Synthesis

Fmoc-D-Phe(2-CF3)-OH (CAS: 352523-15-0) is a trifluoromethylated unnatural amino acid derivative with the molecular formula C25H20F3NO4 and a molecular weight of 455.43 g/mol. This compound is utilised in specialised chemical synthesis and peptide chemistry, particularly in the development of novel peptide-based therapeutics and research tools where the incorporation of a trifluoromethyl group can significantly influence molecular properties and biological activity.

IUPAC: Fmoc-2-(trifluoromethyl)-D-phenylalanine

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Fmoc-D-Phe(2-CF3)-OH (C25H20F3NO4) — chemical structure, CAS 352523-15-0; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical BiologyChemical SynthesisPeptide ChemistryPhenylalanine Derivatives

01 /Applications

Peptide Synthesis

Fmoc-D-Phe(2-CF3)-OH serves as a building block in solid-phase peptide synthesis (SPPS) for incorporating unnatural amino acids into peptide sequences. The trifluoromethyl group can modulate peptide conformation, stability, and receptor binding affinity.

Medicinal Chemistry

This derivative is employed in medicinal chemistry programmes for the design and synthesis of novel drug candidates. Introduction of the trifluoromethylphenylalanine moiety can enhance metabolic stability and lipophilicity of potential therapeutics.

Chemical Biology Research

Used in chemical biology to create modified peptides for probing biological systems or developing new diagnostic agents. The unique properties conferred by the trifluoromethyl group can aid in studying protein-ligand interactions.

02 /Properties

Molecular weight	455.43
Empirical formula	C25H20F3NO4
Assay	≥98.0% (HPLC)
Storage temperature	2-8°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

352523-15-0

MDL number

MFCD01863051

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Fmoc-D-Phe(2-CF3)-OH used for?

Fmoc-D-Phe(2-CF3)-OH is primarily used as a building block in peptide synthesis, medicinal chemistry, and chemical biology research to introduce a trifluoromethylated unnatural amino acid into peptides and potential drug candidates.

What is the CAS number and molecular formula for Fmoc-D-Phe(2-CF3)-OH?

The CAS number is 352523-15-0 and the molecular formula is C25H20F3NO4.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Fmoc-D-Phe(2-CF3)-OH with an assay of ≥98.0% (HPLC). We do not represent this product as USP, BP, or EP grade.

How should Fmoc-D-Phe(2-CF3)-OH be handled and stored?

Handle with appropriate personal protective equipment including eyeshields and gloves. It should be stored at 2-8°C. Refer to the safety data sheet for full handling information.

Is Fmoc-D-Phe(2-CF3)-OH a controlled substance?

The provided data does not indicate that Fmoc-D-Phe(2-CF3)-OH is a controlled substance.

How is this chemical packed, shipped, and exported?

Tech Serve Solutions packs, ships, and exports chemicals according to international regulations and customer requirements, ensuring safe and compliant delivery worldwide.