Fmoc-D-Leu-OH
Fmoc-D-Leu-OH (CAS: 114360-54-2), with the molecular formula C21H23NO4 and a molecular weight of 353.41 g/mol, is a crucial chiral building block for peptide synthesis. It is a derivative of the non-proteinogenic amino acid D-leucine, protected with the Fmoc group. This compound is widely utilised in solid-phase peptide synthesis (SPPS) and solution-phase methodologies for the creation of complex peptides, peptidomimetics, and other biologically relevant molecules.
- IUPAC
- Fmoc-D-leucine
Peptide Synthesis
Fmoc-D-Leu-OH is a fundamental reagent in the Fmoc/tBu solid-phase peptide synthesis (SPPS) strategy. Its D-enantiomer configuration allows for the incorporation of non-natural peptide sequences, offering unique structural and functional properties.
Chemical Biology Research
This derivative serves as a building block in the synthesis of modified peptides for biochemical and biological studies, aiding in the investigation of protein function, enzyme mechanisms, and drug discovery.
Organic Synthesis
Beyond peptide chemistry, Fmoc-D-Leu-OH can be employed in various organic synthesis pathways where a protected chiral leucine moiety is required, contributing to the construction of complex chiral molecules.
| Molecular weight | 353.41 |
|---|---|
| Empirical formula | C21H23NO4 |
| Assay | ≥95.0% (TLC) |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-D-Leu-OH used for?
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Fmoc-D-Leu-OH is primarily used as a protected amino acid building block in solid-phase peptide synthesis (SPPS) and for the creation of peptides, peptidomimetics, and other complex organic molecules in chemical biology and organic synthesis research.
What is the CAS number and molecular formula for Fmoc-D-Leu-OH?
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The CAS number for Fmoc-D-Leu-OH is 114360-54-2, and its molecular formula is C21H23NO4.
What grade and purity does Tech Serve Solutions supply for Fmoc-D-Leu-OH?
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Tech Serve Solutions supplies Fmoc-D-Leu-OH with an assay of ≥95.0% (TLC). This product is intended for research and laboratory use and is not represented as USP, BP, EP, or pharmacopoeia grade.
What are the safety considerations for handling Fmoc-D-Leu-OH?
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When handling Fmoc-D-Leu-OH, it is essential to use personal protective equipment including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used if respiratory protection is needed. The product has a WGK Germany rating of 3.
How is Fmoc-D-Leu-OH supplied and exported by TSS?
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Fmoc-D-Leu-OH is typically stored at 2-8°C and is available for export globally by Tech Serve Solutions, a specialist supplier since 1998.
How can I request a quote or sample for Fmoc-D-Leu-OH?
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To request a quotation or a sample of Fmoc-D-Leu-OH, please contact our customer service team through the TSS website or via the provided contact details.
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